A5ICS3 (LFTR_LEGPC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferase
EC=2.3.2.6

Alternative name(s):
L/F-transferase
Leucyltransferase
Phenyalanyltransferase

Gene names

Name:	aat
Ordered Locus Names:	LPC_1209

Organism

Legionella pneumophila (strain Corby) [Complete proteome] [HAMAP]

Taxonomic identifier

400673 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella › Legionella pneumophila

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine By similarity. HAMAP-Rule MF_00688
Catalytic activity	L-leucyl-tRNA + protein = tRNA + L-leucyl-protein. HAMAP-Rule MF_00688 L-phenylalanyl-tRNA + protein = tRNA + L-phenylalanyl-protein. HAMAP-Rule MF_00688
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the L/F-transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	leucyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Leucyl/phenylalanyl-tRNA--protein transferase HAMAP-Rule MF_00688		PRO_1000045107

Sequences

	Sequence		Length	Mass (Da)
	A5ICS3 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 08EB2209DB9AADE3	FASTA	222	25,473
	10 20 30 40 50 60 MAYDSNYTFP DPETSDKQGL LAIGGVLTPK RVLQAYSQGI FPWYEPGNPV LWWSPNPRLI 70 80 90 100 110 120 LIPNEFKISR SLKKTLKKPF KLTVDTAFQR VISYCATCSD RSNKTWITSE MIETYTQLHE 130 140 150 160 170 180 MGYAHSFEIW DGSELVGGLY GISLGHAFFG ESMFHTITDA SKVALHFLCR IMQSWNFDFI 190 200 210 220 DCQLPTLHLM SLGAKIISRK EFLHMLQETL KYPDKKGNWS ID

References

[1]

"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island." Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Corby.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000675 Genomic DNA. Translation: ABQ55173.1.
RefSeq	YP_001250519.1. NC_009494.2.
3D structure databases
ProteinModelPortal	A5ICS3.
ModBase	Search...
Protein-protein interaction databases
STRING	400673.LPC_1209.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ55173; ABQ55173; LPC_1209.
GeneID	5181030.
KEGG	lpc:LPC_1209.
PATRIC	22308843. VBILegPne45588_1254.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2360.
HOGENOM	HOG000102325.
KO	K00684.
OMA	MFYGESM.
ProtClustDB	PRK00301.
Family and domain databases
HAMAP	MF_00688. Leu_Phe_trans.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR004616. Leu/Phe-tRNA_Trfase. [Graphical view]
Pfam	PF03588. Leu_Phe_trans. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR00667. aat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LFTR_LEGPC

Accession

Primary (citable) accession number: A5ICS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program