Reviewed, UniProtKB/Swiss-Prot A5ICK3 (ASTD_LEGPC)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	LPC_1136

Organism

Legionella pneumophila (strain Corby) [Complete proteome] [HAMAP]

Taxonomic identifier

400673 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_1000065759
Regions
	Nucleotide binding	228 – 233	6	NAD By similarity
Sites
	Active site	251	1	By similarity
	Active site	285	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5ICK3-1 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: EDD2050525341C6E	FASTA	495	54,565
	10 20 30 40 50 60 MSKLQIIQSK GQYINGEWIK GNGLILESTN PASGTLLWQG NNATDEEIAN ACYVAHRALK 70 80 90 100 110 120 SWANTSFEER ARYTKAFVEQ VEKNREQLAR LISLETGKPL WESQTEVSSV IGKVNLSIQA 130 140 150 160 170 180 YQERTWPKQT ETAEANACLR FKPHGIVVVL GAFNFPAHLS NGHIVPALLA GNTVLYKPSE 190 200 210 220 230 240 HTPAVAELII QCWHDSGLPP GVINCLQGNA NCGNTLLSQD IQGVYFTGSY ATGLRIHQQF 250 260 270 280 290 300 CNRPEVILAL EMGGNNPLVI DEVKDIDAAV YHTILSTMIT AGQRCTCARR IIIPDSQTGD 310 320 330 340 350 360 LFLERFAKAC KLMRIGSFDS QPEPFIGPVI SHVQALKHLH AQKQLIEMGG EIILPMSLLL 370 380 390 400 410 420 EYTGLVSPGI IDMTRAKNPP DEEIFAPFAQ IYRYNHFDEA IQLANQTRYG LSAGLLSDNK 430 440 450 460 470 480 DHYQQFYQNI RAGLINWNRP TTGAASSLPF GGVGCSGNHR PSAYFAADYC AYPVASMEQP 490 LLTTPVQRLP GLVLE

References

[1]

"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island." Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000675 Genomic DNA. Translation: ABQ55103.1.
RefSeq	YP_001250449.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5180960.
GenomeReviews	Gene locus LPC_1136 in contig CP000675_GR.
KEGG	lpc:LPC_1136.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_LEGPC

Accession

Primary (citable) accession number: A5ICK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 26, 2007
Last modified:	November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)