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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciLPNE400673:GCIT-1726-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:LPC_1050
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338tRNA pseudouridine synthase DPRO_1000084748Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA5ICB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 303150TRUDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation
Contains 1 TRUD domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000224848.
KOiK06176.
OMAiLWLWVEK.
OrthoDBiEOG6FRCSP.

Family and domain databases

HAMAPiMF_01082. TruD.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5ICB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSLDWPRAY GIPNSTATFK SLPEDFQVNE LFEGQFNGEG EHIVLKIEKR
60 70 80 90 100
GLTTEEVVKS LARLINKPVK LISHAGLKDK QALTTQWLSV HAPGEIIDGI
110 120 130 140 150
ETLEAPGWRI LECTRHNKKL KPGFLSGNHF IITLRNVSDE SDLIHRIEQI
160 170 180 190 200
KFKGVPNYFG EQRFGRDGGN LIKAEEILVQ GRKVKDRFLK GMYFSAARSW
210 220 230 240 250
LYNLILSRRV KESSWNLPLL GDVIQLVGSN SIFVNDKSMD EQLLQRIGEK
260 270 280 290 300
DVSPASPLPG RSKNLVKGTA LQIINDVYEE WSAWLDGLEK NGLEEAWRAN
310 320 330
ILYAEQIEYR INQGTVELSF VLPAGAYATV VLRELVQY
Length:338
Mass (Da):38,310
Last modified:June 26, 2007 - v1
Checksum:i1E6FB46700AD5F59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ55019.1.
RefSeqiWP_011946608.1. NC_009494.2.

Genome annotation databases

EnsemblBacteriaiABQ55019; ABQ55019; LPC_1050.
KEGGilpc:LPC_1050.
PATRICi22308507. VBILegPne45588_1086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ55019.1.
RefSeqiWP_011946608.1. NC_009494.2.

3D structure databases

ProteinModelPortaliA5ICB9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ55019; ABQ55019; LPC_1050.
KEGGilpc:LPC_1050.
PATRICi22308507. VBILegPne45588_1086.

Phylogenomic databases

HOGENOMiHOG000224848.
KOiK06176.
OMAiLWLWVEK.
OrthoDBiEOG6FRCSP.

Enzyme and pathway databases

BioCyciLPNE400673:GCIT-1726-MONOMER.

Family and domain databases

HAMAPiMF_01082. TruD.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
    Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Corby.

Entry informationi

Entry nameiTRUD_LEGPC
AccessioniPrimary (citable) accession number: A5ICB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: November 11, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.