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A5IBR1 (AROA_LEGPC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:LPC_0835
OrganismLegionella pneumophila (strain Corby) [Complete proteome] [HAMAP]
Taxonomic identifier400673 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4334333-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_0000325354

Sequences

Sequence LengthMass (Da)Tools
A5IBR1 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 331712652F4B0D24

FASTA43346,284
        10         20         30         40         50         60 
MLNFISKPVV CLKGEITVPG DKSISHRSII FGAIAIGTSV IDGFLDGEDC IATLKAFQSM 

        70         80         90        100        110        120 
GVRIEGPDKQ RVIIHGVGKY GLKQPQNIID CGNSGTSMRL LAGLLAAQQF DSQLTGDESL 

       130        140        150        160        170        180 
LKRPMLRISR PLSQMGADVT TQDGKPPILI KGGKKLNGIH YVMPEASAQV KSCLLLAGMY 

       190        200        210        220        230        240 
AEGQTKITEN AVSRDHTERM LRTFSYPVQI QDGVIVIDRN GECHGTRLNI PGDISSAAFF 

       250        260        270        280        290        300 
IVAASITPGS DILIRNVGIN PTRTGIIHIL TEMGADIKVL NQRAYGEEPV ADLHIRYSQL 

       310        320        330        340        350        360 
KGIDIPVSMV PLAIDEFPVI FIAAACAQGK TTLHGAKELR LKESDRIGAM VDGLNQLGVH 

       370        380        390        400        410        420 
AEGFDDGILI EGGSIQGGEV NSRGDHRIAM SFAIAGAVAS APVTIKNCAN VATSFPSFVT 

       430 
TANILHFQIE EYS

« Hide

References

[1]"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Corby.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000675 Genomic DNA. Translation: ABQ54811.1.
RefSeqYP_001250157.1. NC_009494.2.

3D structure databases

ProteinModelPortalA5IBR1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5IBR1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5180666.
GenomeReviewsGene locus LPC_0835 in contig CP000675_GR.
KEGGlpc:LPC_0835.
PATRIC22308067. VBILegPne45588_0868.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0128.
HOGENOMHBG646626.
OMAVVMVMAT.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycLPNE400673:LPC_0835-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_LEGPC
AccessionPrimary (citable) accession number: A5IBR1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 26, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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