Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A5IBR0

- SERC_LEGPC

UniProt

A5IBR0 - SERC_LEGPC

Protein

Phosphoserine aminotransferase

Gene

serC

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (26 Jun 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotation

    Catalytic activityi

    O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotation
    4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431L-glutamateUniRule annotation
    Binding sitei103 – 1031Pyridoxal phosphateUniRule annotation
    Binding sitei153 – 1531Pyridoxal phosphateUniRule annotation
    Binding sitei173 – 1731Pyridoxal phosphateUniRule annotation
    Binding sitei196 – 1961Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-serine biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Pyridoxine biosynthesis, Serine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLPNE400673:GCIT-1515-MONOMER.
    UniPathwayiUPA00135; UER00197.
    UPA00244; UER00311.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
    Alternative name(s):
    Phosphohydroxythreonine aminotransferaseUniRule annotation
    Short name:
    PSATUniRule annotation
    Gene namesi
    Name:serCUniRule annotation
    Ordered Locus Names:LPC_0834
    OrganismiLegionella pneumophila (strain Corby)
    Taxonomic identifieri400673 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000001569: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Phosphoserine aminotransferasePRO_1000058215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei197 – 1971N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi400673.LPC_0834.

    Structurei

    3D structure databases

    ProteinModelPortaliA5IBR0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni77 – 782Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1932.
    HOGENOMiHOG000088965.
    KOiK00831.
    OMAiFAAIPMN.
    OrthoDBiEOG60CWP3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00160. SerC_aminotrans_5.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR022278. Pser_aminoTfrase.
    IPR003248. Pser_aminoTfrase_subgr.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000525. SerC. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01364. serC_1. 1 hit.
    PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5IBR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSRVFNFGA GPAMLPEEIL KEAQEEFLNW RNTGMSILEI GHRTPEIINL    50
    LSTAEQSLRE LLNIPKNYHV LFLGGAARAQ FAMIPMNLLQ PGDEAAYFIT 100
    GIWSKMAYHE ANLLKQAYYL SNEEKEGFVS IPDYQKWELK SNTAYVYYTP 150
    NETINGVRFP YVPKTGGVPL VADMTSCLLS EPININQYGL IFAGAQKNIA 200
    NAGLTVVIIH EDLLKNQPEP VIPTMLNYKN HAEHRSLYAT PPVFNCYLAS 250
    KMFEWIKTQG GIEGLFQRNC LKAAKLYQYL DSTDFYLTPV SKEARSIMNI 300
    CFSLCYPDLE QKFLYMANER GLKALKGHRF AGGLRASLYN AMPMAGVDAL 350
    IEFLSEFAKE NG 362
    Length:362
    Mass (Da):40,834
    Last modified:June 26, 2007 - v1
    Checksum:i18D66ABE1496A1B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000675 Genomic DNA. Translation: ABQ54810.1.
    RefSeqiWP_011946432.1. NC_009494.2.
    YP_001250156.1. NC_009494.2.

    Genome annotation databases

    EnsemblBacteriaiABQ54810; ABQ54810; LPC_0834.
    GeneIDi5180665.
    KEGGilpc:LPC_0834.
    PATRICi22308065. VBILegPne45588_0867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000675 Genomic DNA. Translation: ABQ54810.1 .
    RefSeqi WP_011946432.1. NC_009494.2.
    YP_001250156.1. NC_009494.2.

    3D structure databases

    ProteinModelPortali A5IBR0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 400673.LPC_0834.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ54810 ; ABQ54810 ; LPC_0834 .
    GeneIDi 5180665.
    KEGGi lpc:LPC_0834.
    PATRICi 22308065. VBILegPne45588_0867.

    Phylogenomic databases

    eggNOGi COG1932.
    HOGENOMi HOG000088965.
    KOi K00831.
    OMAi FAAIPMN.
    OrthoDBi EOG60CWP3.

    Enzyme and pathway databases

    UniPathwayi UPA00135 ; UER00197 .
    UPA00244 ; UER00311 .
    BioCyci LPNE400673:GCIT-1515-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00160. SerC_aminotrans_5.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR022278. Pser_aminoTfrase.
    IPR003248. Pser_aminoTfrase_subgr.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000525. SerC. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01364. serC_1. 1 hit.
    PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
      Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Corby.

    Entry informationi

    Entry nameiSERC_LEGPC
    AccessioniPrimary (citable) accession number: A5IBR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3