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A5IBR0

- SERC_LEGPC

UniProt

A5IBR0 - SERC_LEGPC

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Protein

Phosphoserine aminotransferase

Gene

serC

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotation

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotation
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationNote: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431L-glutamateUniRule annotation
Binding sitei103 – 1031Pyridoxal phosphateUniRule annotation
Binding sitei153 – 1531Pyridoxal phosphateUniRule annotation
Binding sitei173 – 1731Pyridoxal phosphateUniRule annotation
Binding sitei196 – 1961Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-serine biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Pyridoxine biosynthesis, Serine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLPNE400673:GCIT-1515-MONOMER.
UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
Alternative name(s):
Phosphohydroxythreonine aminotransferaseUniRule annotation
Short name:
PSATUniRule annotation
Gene namesi
Name:serCUniRule annotation
Ordered Locus Names:LPC_0834
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000001569: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Phosphoserine aminotransferasePRO_1000058215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi400673.LPC_0834.

Structurei

3D structure databases

ProteinModelPortaliA5IBR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni77 – 782Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1932.
HOGENOMiHOG000088965.
KOiK00831.
OMAiFAAIPMN.
OrthoDBiEOG60CWP3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5IBR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSRVFNFGA GPAMLPEEIL KEAQEEFLNW RNTGMSILEI GHRTPEIINL
60 70 80 90 100
LSTAEQSLRE LLNIPKNYHV LFLGGAARAQ FAMIPMNLLQ PGDEAAYFIT
110 120 130 140 150
GIWSKMAYHE ANLLKQAYYL SNEEKEGFVS IPDYQKWELK SNTAYVYYTP
160 170 180 190 200
NETINGVRFP YVPKTGGVPL VADMTSCLLS EPININQYGL IFAGAQKNIA
210 220 230 240 250
NAGLTVVIIH EDLLKNQPEP VIPTMLNYKN HAEHRSLYAT PPVFNCYLAS
260 270 280 290 300
KMFEWIKTQG GIEGLFQRNC LKAAKLYQYL DSTDFYLTPV SKEARSIMNI
310 320 330 340 350
CFSLCYPDLE QKFLYMANER GLKALKGHRF AGGLRASLYN AMPMAGVDAL
360
IEFLSEFAKE NG
Length:362
Mass (Da):40,834
Last modified:June 26, 2007 - v1
Checksum:i18D66ABE1496A1B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ54810.1.
RefSeqiWP_011946432.1. NC_009494.2.
YP_001250156.1. NC_009494.2.

Genome annotation databases

EnsemblBacteriaiABQ54810; ABQ54810; LPC_0834.
GeneIDi5180665.
KEGGilpc:LPC_0834.
PATRICi22308065. VBILegPne45588_0867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ54810.1 .
RefSeqi WP_011946432.1. NC_009494.2.
YP_001250156.1. NC_009494.2.

3D structure databases

ProteinModelPortali A5IBR0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400673.LPC_0834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ54810 ; ABQ54810 ; LPC_0834 .
GeneIDi 5180665.
KEGGi lpc:LPC_0834.
PATRICi 22308065. VBILegPne45588_0867.

Phylogenomic databases

eggNOGi COG1932.
HOGENOMi HOG000088965.
KOi K00831.
OMAi FAAIPMN.
OrthoDBi EOG60CWP3.

Enzyme and pathway databases

UniPathwayi UPA00135 ; UER00197 .
UPA00244 ; UER00311 .
BioCyci LPNE400673:GCIT-1515-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00160. SerC_aminotrans_5.
InterProi IPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF000525. SerC. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01364. serC_1. 1 hit.
PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
    Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Corby.

Entry informationi

Entry nameiSERC_LEGPC
AccessioniPrimary (citable) accession number: A5IBR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 26, 2007
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3