Reviewed, UniProtKB/Swiss-Prot A5IBD8 (HGD_LEGPC)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	LPC_0710

Organism

Legionella pneumophila (strain Corby) [Complete proteome] [HAMAP]

Taxonomic identifier

400673 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_1000019530
Sites
	Metal binding	318	1	Iron By similarity
	Metal binding	324	1	Iron By similarity
	Metal binding	354	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5IBD8-1 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 74E1D847B1C870BA	FASTA	416	47,486
	10 20 30 40 50 60 MYLQGFGNYH HSEAVKGALP PNQNSPQHCN LGLYAEQLSG TAFTRPRHNN LRSWLYRILP 70 80 90 100 110 120 TVTQGTYYPY EFNIMHSFVD EFSPNAMRWS PLYNSSQIKC DFVEGLFHIA GSPLVNTYTY 130 140 150 160 170 180 YCNHSMSDKY FANNDGELLF VPYAGEIHLY TEFGKLMLSS GSIAVIPRGV KFKVEVISKE 190 200 210 220 230 240 AKGYLCENSG NPLTLPQLGP IGANGLANPR HFQYPVAAFE DSGGEHTIIC KNQKKLWFTV 250 260 270 280 290 300 CNHSPLNVVA WHGNYAPYCY DLSLFNTINT VSFDHPDPSI FTVLTSESEI PGVSNLDFVI 310 320 330 340 350 360 FPPRWMVAEH TFRPPYFHRN YMNELMGLVY GEYDAKKEGF IPGGISIHNC MTPHGPDYES 370 380 390 400 410 YEIAASQDLK PNYINSLAFM FETKDYWQVT EQAYRHPSRQ VDYLNCWQGF KVEFSQ

References

[1]

"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island." Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000675 Genomic DNA. Translation: ABQ54688.1.
RefSeq	YP_001250034.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5180542.
GenomeReviews	Gene locus LPC_0710 in contig CP000675_GR.
KEGG	lpc:LPC_0710.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A5IBD8. HRNCMSE.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_LEGPC

Accession

Primary (citable) accession number: A5IBD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 26, 2007
Last modified:	May 5, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)