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A5IAU5

- AMPA_LEGPC

UniProt

A5IAU5 - AMPA_LEGPC

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Protein
Probable cytosol aminopeptidase
Gene
pepA, LPC_0510
Organism
Legionella pneumophila (strain Corby)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi252 – 2521Manganese 2 By similarity
Metal bindingi257 – 2571Manganese 1 By similarity
Metal bindingi257 – 2571Manganese 2 By similarity
Active sitei264 – 2641 Reviewed prediction
Metal bindingi275 – 2751Manganese 2 By similarity
Metal bindingi334 – 3341Manganese 1 By similarity
Metal bindingi336 – 3361Manganese 1 By similarity
Metal bindingi336 – 3361Manganese 2 By similarity
Active sitei338 – 3381 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciLPNE400673:GCIT-2852-MONOMER.

    Protein family/group databases

    MEROPSiM17.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidase (EC:3.4.11.1)
    Alternative name(s):
    Leucine aminopeptidase (EC:3.4.11.10)
    Short name:
    LAP
    Leucyl aminopeptidase
    Gene namesi
    Name:pepA
    Ordered Locus Names:LPC_0510
    OrganismiLegionella pneumophila (strain Corby)
    Taxonomic identifieri400673 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000001569: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Probable cytosol aminopeptidaseUniRule annotation
    PRO_1000203833Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi400673.LPC_0510.

    Structurei

    3D structure databases

    ProteinModelPortaliA5IAU5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243132.
    KOiK01255.
    OMAiMPANICT.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5IAU5-1 [UniParc]FASTAAdd to Basket

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    MNYGLTHTPS LTMSECLVLG VFSDLALPDF ATAIDNEQKG LIKKLCQRVP    50
    EPGNTVWQTD VEGHSLLIIQ CGKKEEFSAN SLQKRVGEIT EALIKQRFSS 100
    ATVCLPRLNQ ESAEWQLEQM IVQIDNLRYQ LLDFKTKHAK SHKLESVIFH 150
    LPGATEKSLE MAKAIVTGVE FCRDLANMPA NICTPTYLGE QAISLSKQFD 200
    QISCQVMGPE EIKEMGMGAL LAVAQGSDQP PRLIDIHYHG NKNSTPVILV 250
    GKGITFDSGG LSIKPANAMD EMKYDMSGAA SVLGVIKACA LLKLPINLIG 300
    IIASAENLIS GSAVKSGDIV TTMSGQTVEI INTDAEGRLV LADALTYAER 350
    YNPDFVIDIA TLTGAIIVAL GNIATGYMTR DEQLAKSIER AANESQDKVW 400
    RMPLDEAYQD ALESPLADMI NAGFDRSAGS ITAACFLSRF TEKYRWAHLD 450
    IAGTAWISGK KRNATGRPVP LLIQLLRHVA NSR 483
    Length:483
    Mass (Da):52,613
    Last modified:June 26, 2007 - v1
    Checksum:i695CC2F46D38ACE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000675 Genomic DNA. Translation: ABQ54495.1.
    RefSeqiYP_001249841.1. NC_009494.2.

    Genome annotation databases

    EnsemblBacteriaiABQ54495; ABQ54495; LPC_0510.
    GeneIDi5182305.
    KEGGilpc:LPC_0510.
    PATRICi22307385. VBILegPne45588_0530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000675 Genomic DNA. Translation: ABQ54495.1 .
    RefSeqi YP_001249841.1. NC_009494.2.

    3D structure databases

    ProteinModelPortali A5IAU5.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 400673.LPC_0510.

    Protein family/group databases

    MEROPSi M17.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ54495 ; ABQ54495 ; LPC_0510 .
    GeneIDi 5182305.
    KEGGi lpc:LPC_0510.
    PATRICi 22307385. VBILegPne45588_0530.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243132.
    KOi K01255.
    OMAi MPANICT.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci LPNE400673:GCIT-2852-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
      Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Corby.

    Entry informationi

    Entry nameiAMPA_LEGPC
    AccessioniPrimary (citable) accession number: A5IAU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 26, 2007
    Last modified: June 11, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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