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A5IAB4

- GLSA_LEGPC

UniProt

A5IAB4 - GLSA_LEGPC

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Protein

Glutaminase

Gene
glsA, LPC_0319
Organism
Legionella pneumophila (strain Corby)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671Substrate By similarity
Binding sitei118 – 1181Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciLPNE400673:GCIT-315-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:LPC_0319
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000001569: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310GlutaminaseUniRule annotationPRO_1000079074Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi400673.LPC_0319.

Structurei

3D structure databases

ProteinModelPortaliA5IAB4.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A5IAB4-1 [UniParc]FASTAAdd to Basket

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MSSKLLTIQL LEELVHAAEL NQEGKTADYI PELANVNQEL TAIAVQPLGE    50
KTLAYSNNPL HPVTLQSTGK MIPLIGLLEE FGADQLFEWV KVEPSGDDFA 100
SITRLEQFGP KPSNPMLNAG AIALCSRIPG VGEQQFRWLE HWVQKLFNQR 150
LSINPLVFAS EKRTGNRNRA LAYLLKSRNN LGADVHETLD LYFALCSYEA 200
MLDQMLYLPA VLANRGQDPD TGEQILSIET CKITLAIMAT CGLYDETGTH 250
MVKTGMPAKS GVSGYTIAVV PGKAGIVVLS PRVNAKGNSI RGEIMLEGLS 300
KAMGWHFALP 310
Length:310
Mass (Da):33,893
Last modified:June 26, 2007 - v1
Checksum:i03B5AE9D78CF47A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000675 Genomic DNA. Translation: ABQ54314.1.
RefSeqiYP_001249660.1. NC_009494.2.

Genome annotation databases

EnsemblBacteriaiABQ54314; ABQ54314; LPC_0319.
GeneIDi5182119.
KEGGilpc:LPC_0319.
PATRICi22306997. VBILegPne45588_0341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000675 Genomic DNA. Translation: ABQ54314.1 .
RefSeqi YP_001249660.1. NC_009494.2.

3D structure databases

ProteinModelPortali A5IAB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400673.LPC_0319.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ54314 ; ABQ54314 ; LPC_0319 .
GeneIDi 5182119.
KEGGi lpc:LPC_0319.
PATRICi 22306997. VBILegPne45588_0341.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci LPNE400673:GCIT-315-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
    Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Corby.

Entry informationi

Entry nameiGLSA_LEGPC
AccessioniPrimary (citable) accession number: A5IAB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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