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A5I7P9

- FTHS_CLOBH

UniProt

A5I7P9 - FTHS_CLOBH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBOT413999:GJ72-3670-MONOMER.
    CBOT441771:GIWX-3428-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:CBO3523, CLC_3487
    OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
    Taxonomic identifieri441771 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001986: Chromosome, UP000002409: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000318567Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi413999.CBO3523.

    Structurei

    3D structure databases

    ProteinModelPortaliA5I7P9.
    SMRiA5I7P9. Positions 5-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5I7P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKSDIEIAQ ESKMKNIKNI AEKIGLTEED IDLYGKYKCK ISLDVLKRNK    50
    DKKDGKLILV TAINPTPAGE GKSTVTVGLG QALWKKNKKA VIALREPSLG 100
    PVFGIKGGAA GGGYSQVVPM EDINLHFTGD MHAITSANNL LAAAIDNHIH 150
    QGNILKIDQR RILFKRVMDM NDRALRNVIV ALGGKINGFP REDGFMITVA 200
    SEIMAILCLA EDLMDLKNKM GEILVAYSTE GKPIYCEDLE VQGAMALLMK 250
    DAIKPNLVQT LENTPAIIHG GPFANIAHGC NSILGTKMAL KLGDYVITEA 300
    GFGADLGAEK FFDIKCRKAN LKPNCVVIVA TVRALKYNGG IPKENLKEQN 350
    MEALSKGIKN LGKHIENVNK FGVPAVVAIN KFISDTEEEI EFIKKYCKEL 400
    GAEVSIAEVW EKGGNGGLEL ADKVLDTIEN KESKFNPIYE ETLSIKQKIE 450
    TIAEEIYGAE GVDYSKEAEK QISEIEKLDL DKKPVCMAKT QYSLSDDAKL 500
    LGRPCGFRIN VKEVRISNGA GFIVVLTGNV MTMPGLPKKP AANNMNVLSD 550
    GNIVGLF 557
    Length:557
    Mass (Da):60,743
    Last modified:June 26, 2007 - v1
    Checksum:i5C492C25ED2B538C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000727 Genomic DNA. Translation: ABS38805.1.
    AM412317 Genomic DNA. Translation: CAL85084.1.
    RefSeqiWP_012048375.1. NC_009698.1.
    YP_001256005.1. NC_009495.1.
    YP_001389246.1. NC_009698.1.

    Genome annotation databases

    EnsemblBacteriaiABS38805; ABS38805; CLC_3487.
    GeneIDi5187153.
    5400453.
    KEGGicbh:CLC_3487.
    cbo:CBO3523.
    PATRICi19369205. VBICloBot22612_3501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000727 Genomic DNA. Translation: ABS38805.1 .
    AM412317 Genomic DNA. Translation: CAL85084.1 .
    RefSeqi WP_012048375.1. NC_009698.1.
    YP_001256005.1. NC_009495.1.
    YP_001389246.1. NC_009698.1.

    3D structure databases

    ProteinModelPortali A5I7P9.
    SMRi A5I7P9. Positions 5-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 413999.CBO3523.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS38805 ; ABS38805 ; CLC_3487 .
    GeneIDi 5187153.
    5400453.
    KEGGi cbh:CLC_3487.
    cbo:CBO3523.
    PATRICi 19369205. VBICloBot22612_3501.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CBOT413999:GJ72-3670-MONOMER.
    CBOT441771:GIWX-3428-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.
    2. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.

    Entry informationi

    Entry nameiFTHS_CLOBH
    AccessioniPrimary (citable) accession number: A5I7P9
    Secondary accession number(s): A7G8Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3