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A5I7K8

- EFTU_CLOBH

UniProt

A5I7K8 - EFTU_CLOBH

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Protein

Elongation factor Tu

Gene
tuf1, tufA, CBO3482, CLC_3427
tuf2, tufB, CBO3496, CLC_3441
Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi81 – 855GTP By similarity
Nucleotide bindingi136 – 1394GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT413999:GJ72-3616-MONOMER.
CBOT413999:GJ72-3630-MONOMER.
CBOT441771:GIWX-3374-MONOMER.
CBOT441771:GIWX-3388-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tuf1
Synonyms:tufA
Ordered Locus Names:CBO3482, CLC_3427
AND
Name:tuf2
Synonyms:tufB
Ordered Locus Names:CBO3496, CLC_3441
OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifieri441771 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001986: Chromosome, UP000002409: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Elongation factor TuUniRule annotationPRO_0000337357Add
BLAST

Proteomic databases

PRIDEiA5I7K8.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi413999.CBO3496.

Structurei

3D structure databases

ProteinModelPortaliA5I7K8.
SMRiA5I7K8. Positions 2-397.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 206197tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1 By similarity
Regioni60 – 645G2 By similarity
Regioni81 – 844G3 By similarity
Regioni136 – 1394G4 By similarity
Regioni174 – 1763G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiGTEMCMP.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5I7K8-1 [UniParc]FASTAAdd to Basket

« Hide

MAKAKFERSK PHVNIGTIGH VDHGKTTLTA AITTVLAQKG GASATKYDEI    50
DKAPEEKERG ITINTSHVEY ETANRHYAHV DCPGHADYVK NMITGAAQMD 100
GAILVVSAAD GPMPQTREHI LLASRVGVQY IVVFLNKADQ VDDPELIELV 150
EMEVRELLNE YGFPGDDTPI VVGSALEVLE NQDNAEKTKC IDELMEAIDS 200
YIPTPERATD QPFLMPVEDV FTITGRGTVA TGRVERGVLH TGDEVELIGM 250
KQEVSKTVCT GIEMFRKILD EAMAGDNIGA LLRGIQRDEI QRGQVLAKPG 300
SVTPHKKFVG QVYVLKKEEG GRHTPFFNGY RPQFYFRTTD VTGSINLPEG 350
VEMVMPGDHI DMAVELITPV AMHENLRFAI REGGRTVGSG VVTTISE 397
Length:397
Mass (Da):43,483
Last modified:June 26, 2007 - v1
Checksum:i75AD3C5B65D90FA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000727 Genomic DNA. Translation: ABS37793.1.
CP000727 Genomic DNA. Translation: ABS39226.1.
AM412317 Genomic DNA. Translation: CAL85043.1.
AM412317 Genomic DNA. Translation: CAL85057.1.
RefSeqiYP_001255964.1. NC_009495.1.
YP_001255978.1. NC_009495.1.
YP_001389205.1. NC_009698.1.
YP_001389219.1. NC_009698.1.

Genome annotation databases

EnsemblBacteriaiABS37793; ABS37793; CLC_3441.
ABS39226; ABS39226; CLC_3427.
GeneIDi5187735.
5187740.
5401095.
5401647.
KEGGicbh:CLC_3427.
cbh:CLC_3441.
cbo:CBO3482.
cbo:CBO3496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000727 Genomic DNA. Translation: ABS37793.1 .
CP000727 Genomic DNA. Translation: ABS39226.1 .
AM412317 Genomic DNA. Translation: CAL85043.1 .
AM412317 Genomic DNA. Translation: CAL85057.1 .
RefSeqi YP_001255964.1. NC_009495.1.
YP_001255978.1. NC_009495.1.
YP_001389205.1. NC_009698.1.
YP_001389219.1. NC_009698.1.

3D structure databases

ProteinModelPortali A5I7K8.
SMRi A5I7K8. Positions 2-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413999.CBO3496.

Proteomic databases

PRIDEi A5I7K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS37793 ; ABS37793 ; CLC_3441 .
ABS39226 ; ABS39226 ; CLC_3427 .
GeneIDi 5187735.
5187740.
5401095.
5401647.
KEGGi cbh:CLC_3427.
cbh:CLC_3441.
cbo:CBO3482.
cbo:CBO3496.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OMAi GTEMCMP.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci CBOT413999:GJ72-3616-MONOMER.
CBOT413999:GJ72-3630-MONOMER.
CBOT441771:GIWX-3374-MONOMER.
CBOT441771:GIWX-3388-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.
  2. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.

Entry informationi

Entry nameiEFTU_CLOBH
AccessioniPrimary (citable) accession number: A5I7K8
Secondary accession number(s): A7G8U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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