Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A5I7C2 (A5I7C2_CLOBH) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. SAAS SAAS020622 RuleBase RU004247 HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS020622 HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. RuleBase RU004247 HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site381Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2671Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1361Substrate By similarity HAMAP-Rule MF_01201
Binding site3151Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue381N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
A5I7C2 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 712F9A140EF3F3A3

FASTA38643,175
        10         20         30         40         50         60 
MFRNLRAVWA EIDLDNLQHN LKQIKKICGN KEIIGVIKAN AYGHGAMEIA PTLLENGVSR 

        70         80         90        100        110        120 
LAVAVLSEAM ELRMSGVKEP IMILGYTPWA LGDMLLDNDI EQSVYSYNDA LELSKIAVLK 

       130        140        150        160        170        180 
RKILKIHIVV DTGMGRIGFL PTKESVEDVY KISKLPNIEI EGIFSHFSSA DESDKDYTLY 

       190        200        210        220        230        240 
QMNKYNAFIN KLEEKNIQVP IKHIANSAAI IDLENTHLDA VRAGIIMYGY YPSNYVLRNN 

       250        260        270        280        290        300 
INLKPVMSLK TSIVHIKKVS SGEYISYGRT FKTKRESIIA TLPIGYADGY NRLLSNKGKV 

       310        320        330        340        350        360 
IVNGKLAPVI GRVCMDQCMI DVTFIENLKV GDVVTIMGEE NGVSYTAEDI ASQIGTISYE 

       370        380 
VICNVNKRVP RVYKKDGKII NVVNYI 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes."
Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. expand/collapse author list , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J.
Genome Res. 17:1082-1092(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 3502 EMBL CAL84957.1 and Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger].
[2]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hall EMBL ABS36480.1 and Hall / ATCC 3502 / NCTC 13319 / Type A [Los Alamos].
[3]Shrivastava S., Brinkac L.M., Dodson R.J., Harkins D.M., Durkin A.S., Sutton G.
Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Hall EMBL ABS36480.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000727 Genomic DNA. Translation: ABS36480.1.
AM412317 Genomic DNA. Translation: CAL84957.1.
RefSeqYP_001255879.1. NC_009495.1.
YP_001389121.1. NC_009698.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING413999.CBO3397.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS36480; ABS36480; CLC_3341.
GeneID5186557.
5401733.
KEGGcbh:CLC_3341.
cbo:CBO3397.
PATRIC19368923. VBICloBot22612_3373.

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMARIGISIY.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycCBOT413999:GJ72-3526-MONOMER.
CBOT441771:GIWX-3288-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5I7C2_CLOBH
AccessionPrimary (citable) accession number: A5I7C2
Secondary accession number(s): A7G8K6
Entry history
Integrated into UniProtKB/TrEMBL: June 26, 2007
Last sequence update: June 26, 2007
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)