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A5I705 (G6PI_CLOBH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:CBO3278, CLC_3221
OrganismClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) [Reference proteome] [HAMAP]
Taxonomic identifier441771 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_1000013954

Sites

Active site2911Proton donor By similarity
Active site3121 By similarity
Active site4261 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5I705 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: A80E1468B9389680

FASTA45050,477
        10         20         30         40         50         60 
MKNSLSLDLT KTKPYVEEHE LQYLESIIRE MDNTLGKKTG SGNKFLGWMD LPINYNKEEF 

        70         80         90        100        110        120 
ARIKKAAEKI KNTCDVFIVI GIGGSYLGSR AAIEMISNTF YNNLDKNQRK VPQIYFAGNN 

       130        140        150        160        170        180 
ISSTYMADLL ELVKDKDICV NVISKSGTTT EPAIAFRIFK ELLENKYGKE GAKERIFATT 

       190        200        210        220        230        240 
DAAKGALRTL ADSEGYETFV IPDDVGGRFS VLTPVGLLPI AASGIDIDEM MKGAADAREE 

       250        260        270        280        290        300 
YSSDNIEKNH VYRYVAVRNA LYRKGKTTEM LVNFEPCLHY FGEWWKQLYG ESEGKDGKGI 

       310        320        330        340        350        360 
FPAAADFSTD LHSMGQYIQE GLRNIFETFI NVENPRKSII VKEDKENLDG LNFLADKDMD 

       370        380        390        400        410        420 
YVNHQALRGT VLAHNDGGVP AMVLNVPELS AYYFGQLVYF FEKACGISGY LLGVNPFDQP 

       430        440        450 
GVEAYKKNMF ALLGKPGYEN MKATLEERLK 

« Hide

References

[1]"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes."
Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. expand/collapse author list , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J.
Genome Res. 17:1082-1092(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.
[2]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000727 Genomic DNA. Translation: ABS37962.1.
AM412317 Genomic DNA. Translation: CAL84837.1.
RefSeqYP_001255764.1. NC_009495.1.
YP_001389004.1. NC_009698.1.

3D structure databases

ProteinModelPortalA5I705.
SMRA5I705. Positions 4-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING413999.CBO3278.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS37962; ABS37962; CLC_3221.
GeneID5187535.
5400435.
KEGGcbh:CLC_3221.
cbo:CBO3278.
PATRIC19368683. VBICloBot22612_3254.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100403.
KOK01810.
OMAQVIFIGN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycCBOT413999:GJ72-3402-MONOMER.
CBOT441771:GIWX-3169-MONOMER.
UniPathwayUPA00109; UER00181.
UPA00138.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CLOBH
AccessionPrimary (citable) accession number: A5I705
Secondary accession number(s): A7G889
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways