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A5I5P4

- GLSA_CLOBH

UniProt

A5I5P4 - GLSA_CLOBH

Protein

Glutaminase

Gene

glsA

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611SubstrateUniRule annotation
    Binding sitei113 – 1131SubstrateUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Binding sitei189 – 1891SubstrateUniRule annotation
    Binding sitei241 – 2411SubstrateUniRule annotation
    Binding sitei259 – 2591Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciCBOT413999:GJ72-2895-MONOMER.
    CBOT441771:GIWX-2648-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:CBO2808, CLC_2684
    OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
    Taxonomic identifieri441771 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001986: Chromosome, UP000002409: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305GlutaminasePRO_1000048331Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi413999.CBO2808.

    Structurei

    3D structure databases

    ProteinModelPortaliA5I5P4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiQRARRIN.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5I5P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRLLKTIIE NNRKWISEGK VASYIPELSK MDKNLLGISV CTLGGEEYWE    50
    GDAEVKFTIQ SISKIVTLML AIIDNGEDYV FSKVGMEPTE TAFNSIVNLE 100
    AKESHKPINP MINAGAIVVA SMVAGKDSDE KFDRILKFTR KISGNNDIDI 150
    NLNVYESEKE TGHRNRALAY FMKSTGALKG NVEEILDVYF KQCSIEITCK 200
    DLARIGVMLA NDGVSPYTGD RIVPRHVARI VKTIMVTCGM YDASGNFAVH 250
    IGIPAKSGVG GGIIACAPRR MGIGVLGTAL DEKGNSIAGT KILEELSKQL 300
    DLSIF 305
    Length:305
    Mass (Da):33,286
    Last modified:June 26, 2007 - v1
    Checksum:iB1C813A8CD343350
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000727 Genomic DNA. Translation: ABS37420.1.
    AM412317 Genomic DNA. Translation: CAL84371.1.
    RefSeqiYP_001255309.1. NC_009495.1.
    YP_001388522.1. NC_009698.1.

    Genome annotation databases

    EnsemblBacteriaiABS37420; ABS37420; CLC_2684.
    GeneIDi5185637.
    5400865.
    KEGGicbh:CLC_2684.
    cbo:CBO2808.
    PATRICi19367701. VBICloBot22612_2793.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000727 Genomic DNA. Translation: ABS37420.1 .
    AM412317 Genomic DNA. Translation: CAL84371.1 .
    RefSeqi YP_001255309.1. NC_009495.1.
    YP_001388522.1. NC_009698.1.

    3D structure databases

    ProteinModelPortali A5I5P4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 413999.CBO2808.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS37420 ; ABS37420 ; CLC_2684 .
    GeneIDi 5185637.
    5400865.
    KEGGi cbh:CLC_2684.
    cbo:CBO2808.
    PATRICi 19367701. VBICloBot22612_2793.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi QRARRIN.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci CBOT413999:GJ72-2895-MONOMER.
    CBOT441771:GIWX-2648-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.
    2. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.

    Entry informationi

    Entry nameiGLSA_CLOBH
    AccessioniPrimary (citable) accession number: A5I5P4
    Secondary accession number(s): A7G6V7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3