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Protein

Glutaminase

Gene

glsA

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61SubstrateUniRule annotation1
Binding sitei113SubstrateUniRule annotation1
Binding sitei158SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1
Binding sitei241SubstrateUniRule annotation1
Binding sitei259Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:CBO2808, CLC_2684
OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifieri441771 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001986 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000483311 – 305GlutaminaseAdd BLAST305

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA5I5P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000216890.
KOiK01425.
OMAiANYMKSF.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A5I5P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLLKTIIE NNRKWISEGK VASYIPELSK MDKNLLGISV CTLGGEEYWE
60 70 80 90 100
GDAEVKFTIQ SISKIVTLML AIIDNGEDYV FSKVGMEPTE TAFNSIVNLE
110 120 130 140 150
AKESHKPINP MINAGAIVVA SMVAGKDSDE KFDRILKFTR KISGNNDIDI
160 170 180 190 200
NLNVYESEKE TGHRNRALAY FMKSTGALKG NVEEILDVYF KQCSIEITCK
210 220 230 240 250
DLARIGVMLA NDGVSPYTGD RIVPRHVARI VKTIMVTCGM YDASGNFAVH
260 270 280 290 300
IGIPAKSGVG GGIIACAPRR MGIGVLGTAL DEKGNSIAGT KILEELSKQL

DLSIF
Length:305
Mass (Da):33,286
Last modified:June 26, 2007 - v1
Checksum:iB1C813A8CD343350
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000727 Genomic DNA. Translation: ABS37420.1.
AM412317 Genomic DNA. Translation: CAL84371.1.
RefSeqiWP_003399984.1. NC_009698.1.
YP_001255309.1. NC_009495.1.
YP_001388522.1. NC_009698.1.

Genome annotation databases

EnsemblBacteriaiABS37420; ABS37420; CLC_2684.
GeneIDi5185637.
5400865.
KEGGicbh:CLC_2684.
cbo:CBO2808.
PATRICi19367701. VBICloBot22612_2793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000727 Genomic DNA. Translation: ABS37420.1.
AM412317 Genomic DNA. Translation: CAL84371.1.
RefSeqiWP_003399984.1. NC_009698.1.
YP_001255309.1. NC_009495.1.
YP_001388522.1. NC_009698.1.

3D structure databases

ProteinModelPortaliA5I5P4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS37420; ABS37420; CLC_2684.
GeneIDi5185637.
5400865.
KEGGicbh:CLC_2684.
cbo:CBO2808.
PATRICi19367701. VBICloBot22612_2793.

Phylogenomic databases

HOGENOMiHOG000216890.
KOiK01425.
OMAiANYMKSF.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLSA_CLOBH
AccessioniPrimary (citable) accession number: A5I5P4
Secondary accession number(s): A7G6V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.