Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot A5I4X1 (AROE_CLOBH)

Last modified November 25, 2008. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25
Gene names
Name: aroE
Ordered Locus Names: CBO2540, CLC_2398
OrganismClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier441771 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Shikimate dehydrogenase
PRO_1000021275

Regions

Nucleotide binding125 – 1295NADP By similarity

Sites

Active site651Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
A5I4X1-1 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 5BB7CDDE73F6FCF6

FASTA25829,691
        10         20         30         40         50         60 
MYTTGLIGKN INYSESPEIH NNYYKKNNIP FFYKIFNLKQ DQIDDFIKNL HKNNIKGFNV 

        70         80         90        100        110        120 
TIPYKETILQ YLNDIVYPAD KIGAVNTVAV QEDKLIGYNT DYIGFIKSLQ YYNIQVKNFK 

       130        140        150        160        170        180 
CLIIGSGGSA KCIYYALKEL NARDICIVSR NPEKARLKFE KKVKILNIKD ENKLDRYDLI 

       190        200        210        220        230        240 
VNCTPIGGPN LKEQKPIELK EIKKNCVVYD LNYTPKRSKL LKEAKENGAF IINGEKMLIF 

       250 
QAYSAIGLWC LNGIKGGR 

« Hide

References

[1]"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes."
Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. expand/collapse author list , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J.
Genome Res. 17:1082-1092(2007) [PubMed: 17519437] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000727 Genomic DNA. Translation: ABS37187.1.
AM412317 Genomic DNA. Translation: CAL84094.1.
RefSeqYP_001255038.1.
YP_001388241.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5187986.
5399448.
GenomeReviewsGene locus CBO2540 in contig AM412317_GR.
Gene locus CLC_2398 in contig CP000727_GR.
KEGGcbh:CLC_2398.
cbo:CBO2540.

Organism-specific databases

CMRSearch...

Family and domain databases

HAMAPMF_00222.
[Tree]
InterProIPR016040. NAD(P)-bd.
IPR013708. Shikimate_DHase-bd_N.
IPR006151. Shikm_DHase/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROE_CLOBH
AccessionPrimary (citable) accession number: A5I4X1
Secondary accession number(s): A7G626
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: November 25, 2008
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents