ID   ACKA_CLOBH              Reviewed;         397 AA.
AC   A5I4N7; A7G5T7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   16-JUN-2009, entry version 16.
DE   RecName: Full=Acetate kinase;
DE            EC=2.7.2.1;
DE   AltName: Full=Acetokinase;
GN   Name=ackA; OrderedLocusNames=CBO2458, CLC_2308;
OS   Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441771;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17519437; DOI=10.1101/gr.6282807;
RA   Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA   Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA   Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J.,
RA   Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T.,
RA   Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N.,
RA   Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E.,
RA   Sanders M., Simmonds M., White B., Whithead S., Parkhill J.;
RT   "Genome sequence of a proteolytic (Group I) Clostridium botulinum
RT   strain Hall A and comparative analysis of the clostridial genomes.";
RL   Genome Res. 17:1082-1092(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-
RT   A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + acetate = ADP + acetyl phosphate.
CC   -!- CATALYTIC ACTIVITY: ATP + propanoate = ADP + propanoyl phosphate.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA
CC       biosynthesis; acetyl-CoA from acetate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the acetokinase family.
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DR   EMBL; CP000727; ABS37677.1; -; Genomic_DNA.
DR   EMBL; AM412317; CAL84009.1; -; Genomic_DNA.
DR   RefSeq; YP_001254957.1; -.
DR   RefSeq; YP_001388152.1; -.
DR   GeneID; 5186713; -.
DR   GeneID; 5400371; -.
DR   GenomeReviews; AM412317_GR; CBO2458.
DR   GenomeReviews; CP000727_GR; CLC_2308.
DR   KEGG; cbh:CLC_2308; -.
DR   KEGG; cbo:CBO2458; -.
DR   OMA; A5I4N7; SSDFRDV.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008776; F:acetate kinase activity; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:HAMAP.
DR   HAMAP; MF_00020; -; 1.
DR   InterPro; IPR000890; Acetate_kin.
DR   InterPro; IPR004372; AckA.
DR   PANTHER; PTHR21060; Acetate_kin; 1.
DR   PANTHER; PTHR21060:SF11; AckA; 1.
DR   Pfam; PF00871; Acetate_kinase; 1.
DR   PIRSF; PIRSF000722; Acetate_prop_kin; 1.
DR   PRINTS; PR00471; ACETATEKNASE.
DR   TIGRFAMs; TIGR00016; ackA; 1.
DR   PROSITE; PS01075; ACETATE_KINASE_1; 1.
DR   PROSITE; PS01076; ACETATE_KINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    397       Acetate kinase.
FT                                /FTId=PRO_1000002221.
SQ   SEQUENCE   397 AA;  43430 MW;  AEA792DAF684F2DA CRC64;
     MKILVVNCGS SSLKYQLIDM TSEEALAKGL VERIGIEGSI LTQKVNGEKY IIEEPMKDHK
     KAIELVLKAL VDKEHGVISD MSEIAAVGHR VVHGGEKYAS SVLINDEVMK ALEDCVKLAP
     LHNPPNIIGI NACRELMPKT PMVAVFDTAF HQTLPDYAYM YPLPYELYEQ NGIRKYGFHG
     TSHRYVSSVA SEMMGKDLKD LKVITCHLGN GASLCAVKEG KSVETSMGFT PLAGLAMGTR
     CGDIDPAILL FMERELKMSP DEVDTVINKK SGVLGISGVS SDFRDIEGAA EEGNKRAKLA
     LDVYHYTVRQ TIGAYTAVLN GVDAIVFTAG LGENSAASRE EILNGLEYLG IKIDAEKNKQ
     RGKQIEISTE DSKVKVFVIP TDEELMIARD TKEITVK
//