A5I460 (A5I460_CLOBH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protein-glutamine gamma-glutamyltransferase HAMAP-Rule MF_00727
EC=2.3.2.13 HAMAP-Rule MF_00727

Alternative name(s):
Transglutaminase HAMAP-Rule MF_00727

Gene names

Name:	tgl HAMAP-Rule MF_00727 EMBL ABS38034.1
Ordered Locus Names:	CBO2291 EMBL CAL83831.1, CLC_2219 EMBL ABS38034.1

Organism

Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) [Reference proteome] [HAMAP]

Taxonomic identifier

441771 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium botulinum › Clostridium botulinum A

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links By similarity. HAMAP-Rule MF_00727
Catalytic activity	Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3. HAMAP-Rule MF_00727
Sequence similarities	Belongs to the bacillus TGase family. HAMAP-Rule MF_00727

Ontologies

Keywords
Biological process	Sporulation HAMAP-Rule MF_00727
Molecular function	Acyltransferase HAMAP-Rule MF_00727 EMBL ABS38034.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: HAMAP
Molecular_function	protein-glutamine gamma-glutamyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5I460 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 4FB277152E01D089	FASTA	273	31,777
	10 20 30 40 50 60 MIKISGNTVT RDKIVAKYPP NSLERKIAEQ LSSNQDVHNY DSLNQLEFDI KLRANIVESA 70 80 90 100 110 120 RELDRSDLSF TTFRRSRCNR DYWQRTDEGG FLLKEYVKAS DAIKDIFINT SKYGTECATA 130 140 150 160 170 180 IVIIYYKALL NVLPEQLFNE MFPSIYLFDW QYLDRNLHVE SYGGVTEFFP GDCQYFKNPD 190 200 210 220 230 240 VNPATPEWQG ENVINLGNGT YYGHGIGITS ANGIIRELNR NRRRGATESA FLTDSVTRLN 250 260 270 SKEIFDKYYN FSSTMRIKRS REIHRGYPNY LYY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes." Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J. Genome Res. 17:1082-1092(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 3502 EMBL CAL83831.1 and Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger].
[2]	"Analysis of the Neurotoxin Complex Genes in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, /Ba4 and /B1 Clusters Are Located within Plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hall EMBL ABS38034.1 and Hall / ATCC 3502 / NCTC 13319 / Type A [Los Alamos].
[3]	Shrivastava S., Brinkac L.M., Dodson R.J., Harkins D.M., Durkin A.S., Sutton G. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Hall EMBL ABS38034.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000727 Genomic DNA. Translation: ABS38034.1. AM412317 Genomic DNA. Translation: CAL83831.1.
RefSeq	YP_001254783.1. NC_009495.1. YP_001388063.1. NC_009698.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	413999.CBO2291.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS38034; ABS38034; CLC_2219.
GeneID	5187221. 5398397.
KEGG	cbh:CLC_2219. cbo:CBO2291.
PATRIC	19366645. VBICloBot22612_2265.
Phylogenomic databases
eggNOG	NOG12337.
HOGENOM	HOG000262157.
KO	K00686.
OMA	FECATAI.
ProtClustDB	PRK03187.
Enzyme and pathway databases
BioCyc	CBOT413999:GJ72-2355-MONOMER. CBOT441771:GIWX-2185-MONOMER.
Family and domain databases
HAMAP	MF_00727. Tgl.
InterPro	IPR020916. Gln_gamma-glutamylTfrase_bac. [Graphical view]
ProDom	PD119415. PD119415. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

A5I460_CLOBH

Accession

Primary (citable) accession number: A5I460
Secondary accession number(s): A7G5J8

Entry history

Integrated into UniProtKB/TrEMBL:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)