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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

CBO2208

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

D-threonate 4-phosphate + NAD+ = dihydroxyacetone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Metal bindingi171Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi215Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi270Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei278SubstrateBy similarity1
Binding sitei296SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.-By similarity)
Gene namesi
Ordered Locus Names:CBO2208
OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifieri441771 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001986 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000514981 – 334Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST334

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliA5I3X9.
SMRiA5I3X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000221593.
KOiK00097.
OMAiAPVHKGV.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

A5I3X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINNKPIIGI PIGDPAGVGP EIVVKSLTEA EVYEKCNPIL IGDAKVIKQA
60 70 80 90 100
MGFCNVNLNI NSIKKADEGK FTLGTIDLID LNNIDIDELK IGKVQGIAGK
110 120 130 140 150
AAFEYIKKSV EMAKEGELDA IATTPINKES LREGNVNYIG HTEILADLTD
160 170 180 190 200
TEDPLTMFEV RGMRVFFLTR HVSLRKACDL VTKERVLDYI IRCSEALEKL
210 220 230 240 250
GVKDGKMAVA GLNPHSGEHG LFGDEEMKAV VPAIEEAQKM GYKVEGPIGA
260 270 280 290 300
DSVFHLALKG RYNSVLSLYH DQGHIATKTL DFERTIAVTN GMPILRTSVD
310 320 330
HGTAFDIAGT GQASSVSMVE AIILAAKYSP KFKK
Length:334
Mass (Da):36,273
Last modified:June 26, 2007 - v1
Checksum:iD48D3A5B50A457F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM412317 Genomic DNA. Translation: CAL83749.1.
RefSeqiYP_001254702.1. NC_009495.1.

Genome annotation databases

GeneIDi5186463.
KEGGicbo:CBO2208.
PATRICifig|413999.7.peg.2176.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPDXA2_CLOBH
AccessioniPrimary (citable) accession number: A5I3X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: June 7, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families