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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101UniRule annotation

GO - Molecular functioni

  1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular protein modification process Source: UniProtKB-HAMAP
  2. protein repair Source: InterPro
  3. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCBOT413999:GJ72-1988-MONOMER.
CBOT441771:GIWX-1836-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:CBO1923, CLC_1868
OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifieri441771 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001986: Chromosome, UP000002409: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Peptide methionine sulfoxide reductase MsrAPRO_1000068319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi413999.CBO1923.

Structurei

3D structure databases

ProteinModelPortaliA5I348.
SMRiA5I348. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0225.
HOGENOMiHOG000263863.
KOiK07304.
OMAiLELYWCQ.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

A5I348-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEIVLAGGC FWGVEEYMSR IEGIVETKVG YANGIKENPS YEEVCSGVTG
60 70 80 90 100
HAEACYIKYD ESIISLEELL NKFWSIIDPT VLNKQGNDRG TQYRTGIFYL
110 120 130 140 150
DEKDLNVIIK SKYQEQKNYR KPIVTEVEPL KCFYEAEEYH QKYLKKNPGG

YCHIHLD
Length:157
Mass (Da):18,178
Last modified:June 26, 2007 - v1
Checksum:iE4458E31DD3FC694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000727 Genomic DNA. Translation: ABS38947.1.
AM412317 Genomic DNA. Translation: CAL83465.1.
RefSeqiYP_001254426.1. NC_009495.1.
YP_001387723.1. NC_009698.1.

Genome annotation databases

EnsemblBacteriaiABS38947; ABS38947; CLC_1868.
GeneIDi5186178.
5399299.
KEGGicbh:CLC_1868.
cbo:CBO1923.
PATRICi19365905. VBICloBot22612_1895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000727 Genomic DNA. Translation: ABS38947.1.
AM412317 Genomic DNA. Translation: CAL83465.1.
RefSeqiYP_001254426.1. NC_009495.1.
YP_001387723.1. NC_009698.1.

3D structure databases

ProteinModelPortaliA5I348.
SMRiA5I348. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi413999.CBO1923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS38947; ABS38947; CLC_1868.
GeneIDi5186178.
5399299.
KEGGicbh:CLC_1868.
cbo:CBO1923.
PATRICi19365905. VBICloBot22612_1895.

Phylogenomic databases

eggNOGiCOG0225.
HOGENOMiHOG000263863.
KOiK07304.
OMAiLELYWCQ.
OrthoDBiEOG6091JX.

Enzyme and pathway databases

BioCyciCBOT413999:GJ72-1988-MONOMER.
CBOT441771:GIWX-1836-MONOMER.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.
  2. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.

Entry informationi

Entry nameiMSRA_CLOBH
AccessioniPrimary (citable) accession number: A5I348
Secondary accession number(s): A7G4K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 26, 2007
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.