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A5I348

- MSRA_CLOBH

UniProt

A5I348 - MSRA_CLOBH

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Protein
Peptide methionine sulfoxide reductase MsrA
Gene
msrA, CBO1923, CLC_1868
Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101 By similarity

GO - Molecular functioni

  1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular protein modification process Source: UniProtKB-HAMAP
  2. protein repair Source: InterPro
  3. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCBOT413999:GJ72-1988-MONOMER.
CBOT441771:GIWX-1836-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Gene namesi
Name:msrA
Ordered Locus Names:CBO1923, CLC_1868
OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifieri441771 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001986: Chromosome, UP000002409: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Peptide methionine sulfoxide reductase MsrAUniRule annotation
PRO_1000068319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi413999.CBO1923.

Structurei

3D structure databases

ProteinModelPortaliA5I348.
SMRiA5I348. Positions 1-156.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0225.
HOGENOMiHOG000263863.
KOiK07304.
OMAiQVCSKTT.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

A5I348-1 [UniParc]FASTAAdd to Basket

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MKEIVLAGGC FWGVEEYMSR IEGIVETKVG YANGIKENPS YEEVCSGVTG    50
HAEACYIKYD ESIISLEELL NKFWSIIDPT VLNKQGNDRG TQYRTGIFYL 100
DEKDLNVIIK SKYQEQKNYR KPIVTEVEPL KCFYEAEEYH QKYLKKNPGG 150
YCHIHLD 157
Length:157
Mass (Da):18,178
Last modified:June 26, 2007 - v1
Checksum:iE4458E31DD3FC694
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000727 Genomic DNA. Translation: ABS38947.1.
AM412317 Genomic DNA. Translation: CAL83465.1.
RefSeqiYP_001254426.1. NC_009495.1.
YP_001387723.1. NC_009698.1.

Genome annotation databases

EnsemblBacteriaiABS38947; ABS38947; CLC_1868.
GeneIDi5186178.
5399299.
KEGGicbh:CLC_1868.
cbo:CBO1923.
PATRICi19365905. VBICloBot22612_1895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000727 Genomic DNA. Translation: ABS38947.1 .
AM412317 Genomic DNA. Translation: CAL83465.1 .
RefSeqi YP_001254426.1. NC_009495.1.
YP_001387723.1. NC_009698.1.

3D structure databases

ProteinModelPortali A5I348.
SMRi A5I348. Positions 1-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 413999.CBO1923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS38947 ; ABS38947 ; CLC_1868 .
GeneIDi 5186178.
5399299.
KEGGi cbh:CLC_1868.
cbo:CBO1923.
PATRICi 19365905. VBICloBot22612_1895.

Phylogenomic databases

eggNOGi COG0225.
HOGENOMi HOG000263863.
KOi K07304.
OMAi QVCSKTT.
OrthoDBi EOG6091JX.

Enzyme and pathway databases

BioCyci CBOT413999:GJ72-1988-MONOMER.
CBOT441771:GIWX-1836-MONOMER.

Family and domain databases

Gene3Di 3.30.1060.10. 1 hit.
HAMAPi MF_01401. MsrA.
InterProi IPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view ]
PANTHERi PTHR10173. PTHR10173. 1 hit.
Pfami PF01625. PMSR. 1 hit.
[Graphical view ]
SUPFAMi SSF55068. SSF55068. 1 hit.
TIGRFAMsi TIGR00401. msrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.
  2. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.

Entry informationi

Entry nameiMSRA_CLOBH
AccessioniPrimary (citable) accession number: A5I348
Secondary accession number(s): A7G4K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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