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A5I341

- A5I341_CLOBH

UniProt

A5I341 - A5I341_CLOBH

Protein

Glutamate decarboxylase

Gene

gadA

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciCBOT413999:GJ72-1980-MONOMER.
    CBOT441771:GIWX-1829-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadAImported
    Ordered Locus Names:CBO1917Imported, CLC_1861Imported
    OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)Imported
    Taxonomic identifieri441771 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002409: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi413999.CBO1917.

    Structurei

    3D structure databases

    ProteinModelPortaliA5I341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiPTFQINF.
    OrthoDBiEOG6TFCPW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5I341-1 [UniParc]FASTAAdd to Basket

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    MLYSSKNKQS NDTYATPIFG ITKDKYSIPK YKINENSIAP NIAYRMIKDE    50
    LMNEGNARLN LATFCQTYME DKATKLMAET LQKNAIDKSE YPQTAEIENR 100
    CVNIISDLWN VPKDMNFLGT STVGSSEACM LGGMSMKFRW RDQAKKLGID 150
    INKKKPNLVI SSGYQVCWEK FCVYWDIEMR TVPMDEDNLS LNIDKILDYV 200
    DEYTIGIIGI LGITYTGKFD DIKALDDAIE KYNSNHDIKV YIHVDAASGG 250
    FFTPFINPEI LWDFRLKNVV SINASGHKYG LVYPGIGWIL WKDQEYLPKD 300
    LIFEVSYLGG KMPTLAINFS RSGSQIIGQY YNFLRFGFEG YKKIHERTKE 350
    VAMYISKELE ATGLFSIYND GSNLPIVCYK LKEQSKVKWN LYDLSDRLAM 400
    KGWQIPAYPL PENLNHIIIQ RIVCRSDLGY NLAELLIKDF KTAINDLNNA 450
    HILFHEEENQ GIYGFTH 467
    Length:467
    Mass (Da):53,660
    Last modified:June 26, 2007 - v1
    Checksum:i533231CB09C8E733
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000727 Genomic DNA. Translation: ABS39064.1.
    AM412317 Genomic DNA. Translation: CAL83458.1.
    RefSeqiYP_001254419.1. NC_009495.1.
    YP_001387716.1. NC_009698.1.

    Genome annotation databases

    EnsemblBacteriaiABS39064; ABS39064; CLC_1861.
    GeneIDi5186172.
    5400624.
    KEGGicbh:CLC_1861.
    cbo:CBO1917.
    PATRICi19365891. VBICloBot22612_1888.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000727 Genomic DNA. Translation: ABS39064.1 .
    AM412317 Genomic DNA. Translation: CAL83458.1 .
    RefSeqi YP_001254419.1. NC_009495.1.
    YP_001387716.1. NC_009698.1.

    3D structure databases

    ProteinModelPortali A5I341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 413999.CBO1917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS39064 ; ABS39064 ; CLC_1861 .
    GeneIDi 5186172.
    5400624.
    KEGGi cbh:CLC_1861.
    cbo:CBO1917.
    PATRICi 19365891. VBICloBot22612_1888.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi PTFQINF.
    OrthoDBi EOG6TFCPW.

    Enzyme and pathway databases

    BioCyci CBOT413999:GJ72-1980-MONOMER.
    CBOT441771:GIWX-1829-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 3502Imported.
    2. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HallImported and Hall / ATCC 3502 / NCTC 13319 / Type A [Los Alamos]Imported.
    3. Shrivastava S., Brinkac L.M., Dodson R.J., Harkins D.M., Durkin A.S., Sutton G.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HallImported.

    Entry informationi

    Entry nameiA5I341_CLOBH
    AccessioniPrimary (citable) accession number: A5I341
    Secondary accession number(s): A7G4K1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3