A5I323 (AROK_CLOBH) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 35.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Shikimate kinase Short name=SK EC=2.7.1.71 | ||||
| Gene names |
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| Organism | Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) | ||||
| Taxonomic identifier | 441771 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium |
Protein attributes
| Sequence length | 170 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109 |
| Catalytic activity | ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109 |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109 |
| Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109 |
| Subunit structure | Monomer By similarity. HAMAP MF_00109 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00109. |
| Sequence similarities | Belongs to the shikimate kinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW shikimate kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 170 | 170 | Shikimate kinase HAMAP MF_00109 | PRO_1000094381 | |||||
Regions | |||||||||
| Nucleotide binding | 11 – 16 | 6 | ATP By similarity | ||||||
Sites | |||||||||
| Metal binding | 15 | 1 | Magnesium By similarity | ||||||
| Binding site | 33 | 1 | Substrate By similarity | ||||||
| Binding site | 57 | 1 | Substrate By similarity | ||||||
| Binding site | 79 | 1 | Substrate; via amide nitrogen By similarity | ||||||
| Binding site | 119 | 1 | ATP By similarity | ||||||
| Binding site | 137 | 1 | Substrate By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000727 Genomic DNA. Translation: ABS36174.1. AM412317 Genomic DNA. Translation: CAL83440.1. |
| RefSeq | YP_001254401.1. NC_009495.1. YP_001387698.1. NC_009698.1. |
3D structure databases | |
| ProteinModelPortal | A5I323. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A5I323. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 5186154. 5401294. |
| GenomeReviews | Gene locus CBO1899 in contig AM412317_GR. Gene locus CLC_1843 in contig CP000727_GR. |
| KEGG | cbh:CLC_1843. cbo:CBO1899. |
| PATRIC | 19365857. VBICloBot22612_1871. |
Phylogenomic databases | |
| eggNOG | COG0703. |
| HOGENOM | HBG335815. |
| OMA | MIISERV. |
| ProtClustDB | CLSK912193. |
Enzyme and pathway databases | |
| BioCyc | CBOT36826:CBO1899-MONOMER. CBOT441771:CLC_1843-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00109. Shikimate_kinase. [Tree] |
| InterPro | IPR000623. Shikimate_kinase. [Graphical view] |
| KO | K00891. |
| Pfam | PF01202. SKI. 1 hit. [Graphical view] |
| PRINTS | PR01100. SHIKIMTKNASE. |
| PROSITE | PS01128. SHIKIMATE_KINASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AROK_CLOBH | ||||||||
| Accession | Primary (citable) accession number: A5I323 Secondary accession number(s): A7G4I3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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