A5I2T3 (A5I2T3_CLOBH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glutamate dehydrogenase PIRNR PIRNR000185

Gene names

Name:	gluD EMBL CAL83350.1
Ordered Locus Names:	CBO1811, CLC_1753

Organism

Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)

Taxonomic identifier

441771 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family. RuleBase RU004417 PIRNR PIRNR000185

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU004418 PIRNR PIRNR000185 EMBL CAL83350.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	107	1	By similarity PIRSR PIRSR000185-1

Sequences

	Sequence		Length	Mass (Da)
	A5I2T3 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: BBF774E93079B0B8	FASTA	421	45,613
	10 20 30 40 50 60 MAKENLNPFE NAQKQVKTAC DKLGMEPAVY ELLKEPQRVI EVSIPVKMDD GSVKVFKGYR 70 80 90 100 110 120 SQHNDAVGPT KGGVRFHPNV SLDEVKALSI WMTFKCSVTG IPYGGGKGGI IVDPKTLSKG 130 140 150 160 170 180 ELERLSRGYI DGIHKLIGEK VDVPAPDVNT NGQIMAWMVD EYNKLVGRSA IGVITGKPVE 190 200 210 220 230 240 FGGSLGRNAA TGFGVAVTAR EAAAKLGIDM KKAKLAIQGI GNVGSHTVLN CEKLGGTVVA 250 260 270 280 290 300 LAEWCKEEGT YAIYNENGLD GKAMIEYVKE NGNLLGYPGA KKISLDEFWA LNVDILIPAA 310 320 330 340 350 360 LENAITHENA SSINAKLVCE AANGPITPDA DAILKEKGIT VTPDILTNAG GVTVSYFEWV 370 380 390 400 410 420 QNLYGYYWTE AEVEAKEEEA MVKAFESIWA IKEEYSVTMR EAAYMHSIKK VAGAMKLRGW Y

References

[1]

"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes." Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J. Genome Res. 17:1082-1092(2007) [PubMed: 17519437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger].

[2]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hall / ATCC 3502 / NCTC 13319 / Type A [Los Alamos].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000727 Genomic DNA. Translation: ABS37680.1. AM412317 Genomic DNA. Translation: CAL83350.1.
RefSeq	YP_001254311.1. NC_009495.1. YP_001387608.1. NC_009698.1.
3D structure databases
ProteinModelPortal	A5I2T3.
SMR	A5I2T3. Positions 8-419.
ModBase	Search...
Protein-protein interaction databases
STRING	A5I2T3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5186066. 5401192.
GenomeReviews	Gene locus CBO1811 in contig AM412317_GR. Gene locus CLC_1753 in contig CP000727_GR.
KEGG	cbh:CLC_1753. cbo:CBO1811.
PATRIC	19365679. VBICloBot22612_1782.
Phylogenomic databases
eggNOG	COG0334.
HOGENOM	HBG590661.
OMA	EGFRVQH.
ProtClustDB	CLSK900154.
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DH. IPR006096. Glu/Leu/Phe/Val_DH_C. IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom. IPR014362. Glu_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00260.
Pfam	PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view]
PIRSF	PIRSF000185. Glu_DH. 1 hit.
PRINTS	PR00082. GLFDHDRGNASE.
SMART	SM00839. ELFV_dehydrog. 1 hit. [Graphical view]
PROSITE	PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5I2T3_CLOBH

Accession

Primary (citable) accession number: A5I2T3
Secondary accession number(s): A7G493

Entry history

Integrated into UniProtKB/TrEMBL:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)