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A5I2C8 (A5I2C8_CLOBH) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase 2 HAMAP MF_01201
EC=5.1.1.1 HAMAP MF_01201
Gene names
Name:alr EMBL CAL83195.1
Synonyms:alr-2 EMBL ABS36354.1, alr2 HAMAP MF_01201
Ordered Locus Names:CBO1660, CLC_1685
OrganismClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifier441771 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201

Catalytic activity

L-alanine = D-alanine. SAAS SAAS009006 RuleBase RU000608 HAMAP MF_01201

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS009006 RuleBase RU000608 HAMAP MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. SAAS SAAS009006 RuleBase RU004247 HAMAP MF_01201

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP MF_01201

Sequences

Sequence LengthMass (Da)Tools
A5I2C8 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 832BF5FDCF7C0140

FASTA38943,759
        10         20         30         40         50         60 
MFRNHRPVWE EVNLDNLSYN MRNIKKKVNC KEIFAVVKAN GYGHGALDIA STLLENGATR 

        70         80         90        100        110        120 
LSVACLSEAT ELREGGITCP INILGITPPT LFEDIIDYNI EPVVFSYDCA NQLSKAASLK 

       130        140        150        160        170        180 
NRIVKTHIAV DTGMGRLGFD PTVESLEEIK RIQDLSNIKI EGLCSHFSSS DEKDKSYSEY 

       190        200        210        220        230        240 
QFKIFQNFRK KLIEMNMKIP IYHMSNSAAI IDLPSTYLDG VRAGIILYGY YPSMEVNKEN 

       250        260        270        280        290        300 
LHIKQVMTLK ANIVHIKTID SGKYVGYNRK FKTKRKSKIA ILPLGYGDGY TRFLSNRGKV 

       310        320        330        340        350        360 
IINGQYAPIV GNICMDQCMI DVTDIKEVKV GDEVIIIGKD NINNLRYDAE DIASKVGMTS 

       370        380 
GEIMSIISKR VPRVYIKNGN IVKVRNYIA

« Hide

References

[1]"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes."
Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. expand/collapse author list , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J.
Genome Res. 17:1082-1092(2007) [PubMed: 17519437] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger].
[2]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hall / ATCC 3502 / NCTC 13319 / Type A [Los Alamos].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000727 Genomic DNA. Translation: ABS36354.1.
AM412317 Genomic DNA. Translation: CAL83195.1.
RefSeqYP_001254158.1. NC_009495.1.
YP_001387541.1. NC_009698.1.

3D structure databases

ProteinModelPortalA5I2C8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5I2C8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5185915.
5400037.
GenomeReviewsGene locus CBO1660 in contig AM412317_GR.
Gene locus CLC_1685 in contig CP000727_GR.
KEGGcbh:CLC_1685.
cbo:CBO1660.
PATRIC19365379. VBICloBot22612_1633.

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHBG712172.
OMASVELWGD.
ProtClustDBPRK00053.

Family and domain databases

HAMAPMF_01201. Ala_racemase.
[Tree]
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KOK01775.
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR00492. Alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5I2C8_CLOBH
AccessionPrimary (citable) accession number: A5I2C8
Secondary accession number(s): A7G426
Entry history
Integrated into UniProtKB/TrEMBL: June 26, 2007
Last sequence update: June 26, 2007
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info