A5I2C8 (A5I2C8_CLOBH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine racemase RuleBase RU000608
EC=5.1.1.1 RuleBase RU000608

Gene names

Name:	alr EMBL CAL83195.1
Synonyms:	alr-2 EMBL ABS36354.1
Ordered Locus Names:	CBO1660 EMBL CAL83195.1, CLC_1685 EMBL ABS36354.1

Organism

Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) [Reference proteome] [HAMAP]

Taxonomic identifier

441771 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium botulinum › Clostridium botulinum A

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine = D-alanine. SAAS SAAS020622
Cofactor	Pyridoxal phosphate By similarity. SAAS SAAS020622
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. RuleBase RU004247 SAAS SAAS020622
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate SAAS SAAS020622
Molecular function	Isomerase SAAS SAAS020622 EMBL CAL83195.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5I2C8 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 832BF5FDCF7C0140	FASTA	389	43,759
	10 20 30 40 50 60 MFRNHRPVWE EVNLDNLSYN MRNIKKKVNC KEIFAVVKAN GYGHGALDIA STLLENGATR 70 80 90 100 110 120 LSVACLSEAT ELREGGITCP INILGITPPT LFEDIIDYNI EPVVFSYDCA NQLSKAASLK 130 140 150 160 170 180 NRIVKTHIAV DTGMGRLGFD PTVESLEEIK RIQDLSNIKI EGLCSHFSSS DEKDKSYSEY 190 200 210 220 230 240 QFKIFQNFRK KLIEMNMKIP IYHMSNSAAI IDLPSTYLDG VRAGIILYGY YPSMEVNKEN 250 260 270 280 290 300 LHIKQVMTLK ANIVHIKTID SGKYVGYNRK FKTKRKSKIA ILPLGYGDGY TRFLSNRGKV 310 320 330 340 350 360 IINGQYAPIV GNICMDQCMI DVTDIKEVKV GDEVIIIGKD NINNLRYDAE DIASKVGMTS 370 380 GEIMSIISKR VPRVYIKNGN IVKVRNYIA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes." Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J. Genome Res. 17:1082-1092(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 3502 EMBL CAL83195.1 and Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger].
[2]	"Analysis of the Neurotoxin Complex Genes in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, /Ba4 and /B1 Clusters Are Located within Plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hall EMBL ABS36354.1 and Hall / ATCC 3502 / NCTC 13319 / Type A [Los Alamos].
[3]	Shrivastava S., Brinkac L.M., Dodson R.J., Harkins D.M., Durkin A.S., Sutton G. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Hall EMBL ABS36354.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000727 Genomic DNA. Translation: ABS36354.1. AM412317 Genomic DNA. Translation: CAL83195.1.
RefSeq	YP_001254158.1. NC_009495.1. YP_001387541.1. NC_009698.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	413999.CBO1660.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS36354; ABS36354; CLC_1685.
GeneID	5185915. 5400037.
KEGG	cbh:CLC_1685. cbo:CBO1660.
PATRIC	19365379. VBICloBot22612_1633.
Phylogenomic databases
eggNOG	COG0787.
HOGENOM	HOG000031444.
KO	K01775.
OMA	SIQDYEY.
ProtClustDB	PRK00053.
Enzyme and pathway databases
BioCyc	CBOT413999:GJ72-1715-MONOMER. CBOT441771:GIWX-1653-MONOMER.
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5I2C8_CLOBH

Accession

Primary (citable) accession number: A5I2C8
Secondary accession number(s): A7G426

Entry history

Integrated into UniProtKB/TrEMBL:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)