Reviewed, UniProtKB/Swiss-Prot A5I237 (DEOC_CLOBH)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	deoC
Ordered Locus Names:	CBO1563, CLC_1594

Organism

Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

441771 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000057749
Sites
	Active site	151	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	180	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5I237-1 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 4AC30E951CCFBDCB	FASTA	212	23,060
	10 20 30 40 50 60 MKLSKYIDHT LLKPQATEKD ILKLIEEAKT YDFASVCVNP SWVKLAYENL KDTDVKVCTV 70 80 90 100 110 120 VGFPLGATST ASKVYETKVA IKDGADEIDM VISVGQLKSG NDEYVKEEIK KIVEASKNKL 130 140 150 160 170 180 VKVIIETCLL TEEEKVKACT LSKEAGADYV KTSTGFSTGG AKPEDIKLMR ETVGKDMGVK 190 200 210 ASGGIHTREE MEVMIENGAT RIGASCGVEL VK

References

[1]

"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes." Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J. Genome Res. 17:1082-1092(2007) [PubMed: 17519437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000727 Genomic DNA. Translation: ABS38596.1. AM412317 Genomic DNA. Translation: CAL83102.1.
RefSeq	YP_001254070.1. YP_001387454.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5185818. 5400733.
GenomeReviews	Gene locus CBO1563 in contig AM412317_GR. Gene locus CLC_1594 in contig CP000727_GR.
KEGG	cbh:CLC_1594. cbo:CBO1563.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A5I237. AKMIDHT.
Family and domain databases
HAMAP	MF_00114. [Tree]
InterPro	IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_CLOBH

Accession

Primary (citable) accession number: A5I237
Secondary accession number(s): A7G3T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 26, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)