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Protein

DNA topoisomerase

Gene

CBO1506

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Enzyme and pathway databases

BioCyciCBOT413999:GJ72-1567-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseSAAS annotation (EC:5.99.1.2SAAS annotation)
Gene namesi
Ordered Locus Names:CBO1506Imported
OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)Imported
Taxonomic identifieri441771 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001986 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA5I1Y4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 145144ToprimInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type IA topoisomerase family.SAAS annotation
Contains Toprim domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000086847.
KOiK03169.
OMAiRVMETCG.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 2 hits.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5I1Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLLLAEKP SVARNIGEAL GCKTRKNGYL EGNGYIVTWA FGHLLTLYDC
60 70 80 90 100
KDYDHKLALW SFENFPYIPT EFKYKVKNDG KNRNVVDAGA KKQLEIIKEL
110 120 130 140 150
INRGDVEEII SATDYDREGE LIALLIFNYL KANKPIYRIL INEWTPTEIK
160 170 180 190 200
KGLKDLKKNE EMISLQDAGV SRQLADWVIG INFTSIATMK YTRGKGNLLN
210 220 230 240 250
IGRVLMPTLK IIYDREIEIK NFKVEEFYEL EATFKNKKGE YKGKFFYEKK
260 270 280 290 300
EKFPNKKIME KLKAEIKDKS GLVTEKTIEI KKENPPSLFN LSNLQGYITS
310 320 330 340 350
KYKGFTADKV LKVAQSLYEK KHITYPRTES TALEESIKDK AKKVLEVLKN
360 370 380 390 400
DLPFKDEIIF NTSKKVFNNA KVESHSAIMP TYIIPKNLTP DERLVYDAIK
410 420 430 440 450
NRFISQFMKE AQYENTEIVT TVPGENYERL FKTKGKILKC KGWLKLYKEK
460 470 480 490 500
KKDELLPPIE KDDEVEIKSL KIISKKTKPP AHHTEKTLLK AMETCGKNTK
510 520 530 540 550
QSEDNEEESN ILYGYSIGTA ATRAETINKL KYAGYITPKG KSLLITDKGT
560 570 580 590 600
KLIETFPIRE LLDTDYTGKL EKKLYDMEKG KFKKEDFLKE IFNFTVNGVN
610
KIKNIRSNVI CDTRVKKDK
Length:619
Mass (Da):71,500
Last modified:June 26, 2007 - v1
Checksum:i66CD90B6FCF33339
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM412317 Genomic DNA. Translation: CAL83048.1.
RefSeqiYP_001254018.1. NC_009495.1.

Genome annotation databases

GeneIDi5185761.
KEGGicbo:CBO1506.
PATRICi19365079. VBICloBot22612_1483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM412317 Genomic DNA. Translation: CAL83048.1.
RefSeqiYP_001254018.1. NC_009495.1.

3D structure databases

ProteinModelPortaliA5I1Y4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5185761.
KEGGicbo:CBO1506.
PATRICi19365079. VBICloBot22612_1483.

Phylogenomic databases

HOGENOMiHOG000086847.
KOiK03169.
OMAiRVMETCG.

Enzyme and pathway databases

BioCyciCBOT413999:GJ72-1567-MONOMER.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 2 hits.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA5I1Y4_CLOBH
AccessioniPrimary (citable) accession number: A5I1Y4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 26, 2007
Last sequence update: June 26, 2007
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.