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A5I0I2 (ADD_CLOBH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase

EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:CBO0991, CLC_1043
OrganismClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifier441771 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Adenosine deaminase HAMAP MF_00540
PRO_1000017655

Sites

Active site2001Proton donor By similarity
Metal binding121Zinc; catalytic By similarity
Metal binding141Zinc; catalytic By similarity
Metal binding1971Zinc; catalytic By similarity
Metal binding2781Zinc; catalytic By similarity
Binding site141Substrate By similarity
Binding site161Substrate By similarity
Site2211Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A5I0I2 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 4F815579CB190B07

FASTA33537,683
        10         20         30         40         50         60 
MNFKKLPKIE LHCHLDGSLR IDTILDIAKK DNIPLPSYNK KELINYVSIM DDCNSLDEYL 

        70         80         90        100        110        120 
NKFFIPNKVM QTKENLKRIA FELLEDVAAD NVKYIEVRFA PLLHVEKGLN IEEIIESVLA 

       130        140        150        160        170        180 
GIKEAEKLYD IKGNLILGCM RNMDIPSAFE VVKKGAKFIG KGVVAIDLCA GEEPHFPGKY 

       190        200        210        220        230        240 
IEVLKLAKEC GYRITIHAGE AGVGENVLEA INLLNAERIG HGIYIKNCAE AYKLVKEKNI 

       250        260        270        280        290        300 
PLEVCPTSNL HTKAFESYET HPFMDFLKDG IKVTINTDNM TVSNTTITKE LEMLNKFCGL 

       310        320        330 
SIEDYKILYL NAVEASFASP ETKEILKSYA NEITA 

« Hide

References

[1]"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes."
Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. expand/collapse author list , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J.
Genome Res. 17:1082-1092(2007) [PubMed: 17519437] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.
[2]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hall / ATCC 3502 / NCTC 13319 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000727 Genomic DNA. Translation: ABS37648.1.
AM412317 Genomic DNA. Translation: CAL82543.1.
RefSeqYP_001253522.1. NC_009495.1.
YP_001386911.1. NC_009698.1.

3D structure databases

ProteinModelPortalA5I0I2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5I0I2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5185246.
5399812.
GenomeReviewsGene locus CBO0991 in contig AM412317_GR.
Gene locus CLC_1043 in contig CP000727_GR.
KEGGcbh:CLC_1043.
cbo:CBO0991.
PATRIC19364085. VBICloBot22612_0986.

Phylogenomic databases

eggNOGCOG1816.
HOGENOMHBG630382.
OMAPYYMAMN.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycCBOT36826:CBO0991-MONOMER.
CBOT441771:CLC_1043-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_CLOBH
AccessionPrimary (citable) accession number: A5I0I2
Secondary accession number(s): A7FZQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families