A5HZW1 (A5HZW1_CLOBH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative phage-related deoxyuridylate hydroxymethyltransferase EMBL CAL82322.1
EC=2.1.2.- EMBL CAL82322.1

Submitted name:
Thymidylate synthase EMBL ABS37044.1
EC=2.1.1.45 EMBL ABS37044.1

Gene names

Name:	thyA EMBL ABS37044.1
Ordered Locus Names:	CBO0768, CLC_0824

Organism

Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)

Taxonomic identifier

441771 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Molecular function	Methyltransferase SAAS SAAS023451 EMBL CAL82322.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5HZW1 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 7E384738BFA5ABF6	FASTA	324	38,963
	10 20 30 40 50 60 MKFKNFHEAY IKNLNDVYYN PEFINQPRGN VSKERLNYFM ILENPRERIC YTKSRKTNII 70 80 90 100 110 120 FNFAEALWYL SGSNDLDYIS YYASNMKKYS MDGKTLTGTA YGPKIFSYGY NKINQWNRII 130 140 150 160 170 180 KLFKEDPDTK RGFIEIFDAN EDLSLKNIDV SCTIGFQFFI REHKLYMTTF MRANDAYRGI 190 200 210 220 230 240 ISDVFSFTFI QEFLATELNL DIGQYSHQVA TTHIYEPDFK LAEKVLCESK SAKKELSFPR 250 260 270 280 290 300 MPKKDNWEDL KIVLQYEKEL RKQSIHLTKK DIDELEIDKY WKQIICLFVL YQEIYYGDNL 310 320 DYEIYESLEP LYQYLFSNKW NQYF

References

[1]

"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes." Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J. Genome Res. 17:1082-1092(2007) [PubMed: 17519437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger].

[2]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hall / ATCC 3502 / NCTC 13319 / Type A [Los Alamos].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000727 Genomic DNA. Translation: ABS37044.1. AM412317 Genomic DNA. Translation: CAL82322.1.
RefSeq	YP_001253305.1. NC_009495.1. YP_001386700.1. NC_009698.1.
3D structure databases
ProteinModelPortal	A5HZW1.
ModBase	Search...
Protein-protein interaction databases
STRING	A5HZW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5185023. 5399383.
GenomeReviews	Gene locus CBO0768 in contig AM412317_GR. Gene locus CLC_0824 in contig CP000727_GR.
KEGG	cbh:CLC_0824. cbo:CBO0768.
PATRIC	19363643. VBICloBot22612_0765.
Phylogenomic databases
eggNOG	COG0207.
HOGENOM	HBG338578.
OMA	DIPRMKL.
ProtClustDB	CLSK931335.
Family and domain databases
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KO	K00560.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5HZW1_CLOBH

Accession

Primary (citable) accession number: A5HZW1
Secondary accession number(s): A7G1R1

Entry history

Integrated into UniProtKB/TrEMBL:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)