A5HZN9 (A5HZN9_CLOBH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aminomethyltransferase 1 HAMAP MF_00259
EC=2.1.2.10 HAMAP MF_00259

Alternative name(s):
Glycine cleavage system T protein 1 HAMAP MF_00259

Gene names

Name:	gcvT EMBL CAL82248.1
Synonyms:	gcvT1 HAMAP MF_00259
Ordered Locus Names:	CBO0696

Organism

Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)

Taxonomic identifier

441771 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259 RuleBase RU003981 SAAS SAAS022903
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259 RuleBase RU003981 SAAS SAAS022903
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP MF_00259 RuleBase RU003981 SAAS SAAS022903
Sequence similarities	Belongs to the GcvT family. HAMAP MF_00259 RuleBase RU003980

Ontologies

Keywords
Molecular function	Aminotransferase HAMAP MF_00259 SAAS SAAS022903 RuleBase RU003981 Methyltransferase EMBL CAL82248.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5HZN9 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 9C5F2D630A71E1F5	FASTA	375	42,182
	10 20 30 40 50 60 MGVKHMKDLK VTPLRGVYEE YGGKIVDFAG YELPTQFKGF LHEHHTVREK AGLFDVSHMG 70 80 90 100 110 120 EAMVTGKDAG KFIQYLMTND INVLKDNEVL YTFMCNEDGG VIDDLLVYKF AEDEFFLVIN 130 140 150 160 170 180 ASNKDKDVKW IMDHKGDFDV EIVDVSDSIA QLAFQGPLAE EILQKIVDVD LQEIKFFKLK 190 200 210 220 230 240 RDVLVNGKKC LVSRTGYTGE DGFEIYCKPE DAKGLWHAIL NAGKEEGAQP IGLGARDTLR 250 260 270 280 290 300 FEASLLLYGN EMDETITPLE VGMGFFAKLK IEEDFIGKDA LIKQKAEGVT RKLVGFELLD 310 320 330 340 350 360 KGIPRHGYEV IKDGKVIGHV TTGYKSPTLN KAIGLALVEE QYSKIGTEFN IKVRKKELKA 370 VAIDKRFYTK KTKTK

References

[1]

"Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes." Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G., Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L., Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T. , Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., White B., Whithead S., Parkhill J. Genome Res. 17:1082-1092(2007) [PubMed: 17519437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM412317 Genomic DNA. Translation: CAL82248.1.
RefSeq	YP_001253237.1. NC_009495.1.
3D structure databases
ProteinModelPortal	A5HZN9.
SMR	A5HZN9. Positions 9-367.
ModBase	Search...
Protein-protein interaction databases
STRING	A5HZN9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5184951.
GenomeReviews	Gene locus CBO0696 in contig AM412317_GR.
KEGG	cbo:CBO0696.
PATRIC	19363497. VBICloBot22612_0692.
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	VINASNK.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5HZN9_CLOBH

Accession

Primary (citable) accession number: A5HZN9

Entry history

Integrated into UniProtKB/TrEMBL:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)