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Protein
Submitted name:

Transporter associated with antigen presentation 2

Gene

TAP2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi501 – 508ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-1236974 ER-Phagosome pathway
R-GGA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Submitted name:
Transporter associated with antigen presentation 2Imported
Submitted name:
Transporter associated with antigen processing 2Imported
Gene namesi
Name:TAP2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 84HelicalSequence analysisAdd BLAST19
Transmembranei104 – 127HelicalSequence analysisAdd BLAST24
Transmembranei139 – 163HelicalSequence analysisAdd BLAST25
Transmembranei183 – 206HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSGALG00000000181

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000236

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 433ABC transmembrane type-1InterPro annotationAdd BLAST281
Domaini466 – 701ABC transporterInterPro annotationAdd BLAST236

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
HOVERGENiHBG008358
KOiK05654
OMAiFNQFFVG
OrthoDBiEOG091G02J6

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR005293 Tap2/ABCB3
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PRINTSiPR01897 TAP2PROTEIN
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5HUM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMPPYILRL SCTLLLADLA LMLALAHFFP ALAHLGWVGS WLEAGLRLLV
60 70 80 90 100
LGGAGQLLAP RGPHGAAVLL SLGPAIFLTL RGYVGLPGAA PVLLAMATPS
110 120 130 140 150
WLVLTHGTAV VALLTWSLLV PTVATGAKEA EAWVPLRRLL ALAWPEWPFL
160 170 180 190 200
GCAFLFLALA ALGETSVPYC TGRALDVLRQ GDGLAAFTAA VGLMCLASAS
210 220 230 240 250
SSLFAGCRGG LFTFIRFRFV LRTRDQLFSS LVYRDLAFFQ KTTAAELASR
260 270 280 290 300
LTTDVTLASN VLALNINVML RNLGQVLGLC AFMLGLSPRL TMLALLEVPL
310 320 330 340 350
AVTARKVYDT RHQMLQRAVL DAAANTGAAV QESISSIEMV RVFNGEEEEE
360 370 380 390 400
YRYSQVLDRT LRLRDQRDTE RAIFLLIQRV LQLAVQALVL YCGHQQLREG
410 420 430 440 450
TLTAGSLVAF ILYQTKAGSC VQALAYSYGD LLSNAVAACK VFDYLDWERA
460 470 480 490 500
VGAGGTYVPT RLRGHVTFHR VSFAYPTRPE RLVLQDVTFE LRPGEVTALA
510 520 530 540 550
GLNGSGKSTC VALLERFYEP GAGEVLLDGV PLRDYEHRYL HRQVALVGQE
560 570 580 590 600
PVLFSGSIRD NIAYGMEDCE EEEIIAAAKA AGALGFISAL EQGFGTDVGE
610 620 630 640 650
RGGQLSAGQK QRIAIARALV RRPTVLILDE ATSALDGDSD AMLQQWVRNG
660 670 680 690 700
GDRTVLLITH QPRMLEKADR VVVLEHGTVA EMGTPAELRT RGGPYSRLLQ

H
Length:701
Mass (Da):75,942
Last modified:June 26, 2007 - v1
Checksum:i03C204DB7CD91448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000555 Genomic DNA No translation available.
JF794490 mRNA Translation: AEE25625.1
AB268588 Genomic DNA Translation: BAF63005.1
AB426152 Genomic DNA Translation: BAG69454.1
RefSeqiNP_001092827.1, NM_001099357.1
XP_015150476.1, XM_015294990.1
XP_015150477.1, XM_015294991.1
UniGeneiGga.2865

Genome annotation databases

EnsembliENSGALT00000051475; ENSGALP00000044374; ENSGALG00000029381
GeneIDi427728
KEGGigga:427728

Similar proteinsi

Entry informationi

Entry nameiA5HUM1_CHICK
AccessioniPrimary (citable) accession number: A5HUM1
Secondary accession number(s): F1NS76
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2007
Last sequence update: June 26, 2007
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health