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Protein
Submitted name:

Transporter associated with antigen presentation 2

Gene

TAP2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
Transporter associated with antigen presentation 2Imported
Submitted name:
Transporter associated with antigen processing 2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:TAP2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8419HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12724HelicalSequence analysisAdd
BLAST
Transmembranei139 – 16325HelicalSequence analysisAdd
BLAST
Transmembranei183 – 20624HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000236.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 433281ABC transmembrane type-1InterPro annotationAdd
BLAST
Domaini466 – 701236ABC transporterInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transporter domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
KOiK05654.
OMAiYNTRHQA.
OrthoDBiEOG7Z3F4H.
TreeFamiTF105196.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005293. Tap2/ABCB3.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSiPR01897. TAP2PROTEIN.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5HUM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMPPYILRL SCTLLLADLA LMLALAHFFP ALAHLGWVGS WLEAGLRLLV
60 70 80 90 100
LGGAGQLLAP RGPHGAAVLL SLGPAIFLTL RGYVGLPGAA PVLLAMATPS
110 120 130 140 150
WLVLTHGTAV VALLTWSLLV PTVATGAKEA EAWVPLRRLL ALAWPEWPFL
160 170 180 190 200
GCAFLFLALA ALGETSVPYC TGRALDVLRQ GDGLAAFTAA VGLMCLASAS
210 220 230 240 250
SSLFAGCRGG LFTFIRFRFV LRTRDQLFSS LVYRDLAFFQ KTTAAELASR
260 270 280 290 300
LTTDVTLASN VLALNINVML RNLGQVLGLC AFMLGLSPRL TMLALLEVPL
310 320 330 340 350
AVTARKVYDT RHQMLQRAVL DAAANTGAAV QESISSIEMV RVFNGEEEEE
360 370 380 390 400
YRYSQVLDRT LRLRDQRDTE RAIFLLIQRV LQLAVQALVL YCGHQQLREG
410 420 430 440 450
TLTAGSLVAF ILYQTKAGSC VQALAYSYGD LLSNAVAACK VFDYLDWERA
460 470 480 490 500
VGAGGTYVPT RLRGHVTFHR VSFAYPTRPE RLVLQDVTFE LRPGEVTALA
510 520 530 540 550
GLNGSGKSTC VALLERFYEP GAGEVLLDGV PLRDYEHRYL HRQVALVGQE
560 570 580 590 600
PVLFSGSIRD NIAYGMEDCE EEEIIAAAKA AGALGFISAL EQGFGTDVGE
610 620 630 640 650
RGGQLSAGQK QRIAIARALV RRPTVLILDE ATSALDGDSD AMLQQWVRNG
660 670 680 690 700
GDRTVLLITH QPRMLEKADR VVVLEHGTVA EMGTPAELRT RGGPYSRLLQ

H
Length:701
Mass (Da):75,942
Last modified:June 26, 2007 - v1
Checksum:i03C204DB7CD91448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03007224 Genomic DNA. No translation available.
JF794490 mRNA. Translation: AEE25625.1.
AB268588 Genomic DNA. Translation: BAF63005.1.
AB426152 Genomic DNA. Translation: BAG69454.1.
RefSeqiNP_001092827.1. NM_001099357.1.
XP_015150476.1. XM_015294990.1.
XP_015150477.1. XM_015294991.1.
UniGeneiGga.2865.

Genome annotation databases

EnsembliENSGALT00000000237; ENSGALP00000000236; ENSGALG00000000181.
GeneIDi427728.
KEGGigga:427728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03007224 Genomic DNA. No translation available.
JF794490 mRNA. Translation: AEE25625.1.
AB268588 Genomic DNA. Translation: BAF63005.1.
AB426152 Genomic DNA. Translation: BAG69454.1.
RefSeqiNP_001092827.1. NM_001099357.1.
XP_015150476.1. XM_015294990.1.
XP_015150477.1. XM_015294991.1.
UniGeneiGga.2865.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000236.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000237; ENSGALP00000000236; ENSGALG00000000181.
GeneIDi427728.
KEGGigga:427728.

Organism-specific databases

CTDi6891.

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
KOiK05654.
OMAiYNTRHQA.
OrthoDBiEOG7Z3F4H.
TreeFamiTF105196.

Enzyme and pathway databases

ReactomeiR-GGA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

PROiA5HUM1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005293. Tap2/ABCB3.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSiPR01897. TAP2PROTEIN.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. "Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease."
    Shiina T., Briles W.E., Goto R.M., Hosomichi K., Yanagiya K., Shimizu S., Inoko H., Miller M.M.
    J. Immunol. 178:7162-7172(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Contribution of mutation, recombination, and gene conversion to chicken MHC-B haplotype diversity."
    Hosomichi K., Miller M.M., Goto R.M., Wang Y., Suzuki S., Kulski J.K., Nishibori M., Inoko H., Hanzawa K., Shiina T.
    J. Immunol. 181:3393-3399(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Cornell-NImported.
  4. "The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes."
    Walker B.A., Hunt L.G., Sowa A.K., Skjodt K., Gobel T.W., Lehner P.J., Kaufman J.
    Proc. Natl. Acad. Sci. U.S.A. 108:8396-8401(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiA5HUM1_CHICK
AccessioniPrimary (citable) accession number: A5HUM1
Secondary accession number(s): F1NS76
Entry historyi
Integrated into UniProtKB/TrEMBL: June 26, 2007
Last sequence update: June 26, 2007
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.