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Protein

Myeloid differentiation primary response protein MyD88

Gene

MYD88

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-GGA-209543 p75NTR recruits signalling complexes
R-GGA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-GGA-433822 NFkB and MAPK activation mediated by TRAF6
R-GGA-451477 MyD88-dependent cascade initiated on endosome membrane
R-GGA-451514 MyD88:TIRAP-dependent cascade initiated on plasma membrane
R-GGA-573298 NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation
R-GGA-9013973 TICAM1-dependent activation of IRF3/IRF7
R-GGA-9020702 Interleukin-1 signaling
R-GGA-933541 TRAF6 mediated IRF7 activation
R-GGA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-GGA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-GGA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-GGA-975155 MyD88 dependent cascade initiated on endosome
R-GGA-977240 MyD88 cascade initiated on plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid differentiation primary response protein MyD88
Gene namesi
Name:MYD88
ORF Names:RCJMB04_14h3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003931401 – 299Myeloid differentiation primary response protein MyD88Add BLAST299

Proteomic databases

PaxDbiA5HNF6
PRIDEiA5HNF6

Expressioni

Tissue specificityi

Expressed in spleen, liver, kidney, bursa of Fabricius, lung and brain (at protein level). Expressed in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus, bursa of Fabricius, muscle and lung.2 Publications

Gene expression databases

BgeeiENSGALG00000005947
ExpressionAtlasiA5HNF6 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009551

Structurei

3D structure databases

ProteinModelPortaliA5HNF6
SMRiA5HNF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 113DeathPROSITE-ProRule annotationAdd BLAST80
Domaini162 – 299TIRPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 158Intermediate domainBy similarityAdd BLAST45

Domaini

The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.By similarity

Phylogenomic databases

eggNOGiENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA
GeneTreeiENSGT00510000048324
HOVERGENiHBG052547
InParanoidiA5HNF6
KOiK04729
PhylomeDBiA5HNF6

Family and domain databases

CDDicd08312 Death_MyD88, 1 hit
Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR034249 MyD88_Death
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR15079 PTHR15079, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF13676 TIR_2, 1 hit
PIRSFiPIRSF037756 MyD88, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

A5HNF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPVGAGS APGPEPADLH SVPMVALNYG VRRRLGLYLN PRAATAADWT
60 70 80 90 100
ALAEKLGHDY LEIRRLEALP DPTAALLEEW QSRCPGGATV GQLLELLRQL
110 120 130 140 150
GRHDVLLELG GSVEEDCKKY LRRKQQEAEQ PLQVPAVDSS VPKTSELMGI
160 170 180 190 200
TTRDDPYGHG TEMFDAFICY CQKDLQFVQE MIRELEQTEF KLKLCVFDRD
210 220 230 240 250
VLPGTCVWSI SGELIERRCR RMVVVISDDY LESDECDFQT KFALSLSPGA
260 270 280 290
RLKRLIPVKC KTMKNEFPSI LRFITICDYT NPCTKKWFWT RLAKSLLLP
Length:299
Mass (Da):33,781
Last modified:June 12, 2007 - v1
Checksum:i62138CF9E06B02B3
GO

Sequence cautioni

The sequence ABJ98316 differs from that shown. Reason: Frameshift at position 287.Curated
The sequence CAH65274 differs from that shown. Reason: Frameshift at position 287.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF011109 mRNA Translation: ABJ98316.1 Frameshift.
EF544486 mRNA Translation: ABQ17966.1
AJ851640 mRNA Translation: CAH65274.1 Frameshift.
RefSeqiNP_001026133.2, NM_001030962.3
UniGeneiGga.17397

Genome annotation databases

EnsembliENSGALT00000044477; ENSGALP00000042597; ENSGALG00000005947
GeneIDi420420
KEGGigga:420420

Similar proteinsi

Entry informationi

Entry nameiMYD88_CHICK
AccessioniPrimary (citable) accession number: A5HNF6
Secondary accession number(s): A0FIQ0, Q5F3L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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