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Protein

Myeloid differentiation primary response protein MyD88

Gene

MYD88

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-GGA-209543. p75NTR recruits signalling complexes.
R-GGA-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-GGA-433822. NFkB and MAPK activation mediated by TRAF6.
R-GGA-446652. Interleukin-1 signaling.
R-GGA-451477. MyD88-dependent cascade initiated on endosome membrane.
R-GGA-451514. MyD88:TIRAP-dependent cascade initiated on plasma membrane.
R-GGA-573298. NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation.
R-GGA-933541. TRAF6 mediated IRF7 activation.
R-GGA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
R-GGA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-GGA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-GGA-975155. MyD88 dependent cascade initiated on endosome.
R-GGA-977240. MyD88 cascade initiated on plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid differentiation primary response protein MyD88
Gene namesi
Name:MYD88
ORF Names:RCJMB04_14h3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Predominantly cytoplasmic, with some expression in the nucleus.

GO - Cellular componenti

  • cytoplasm Source: AgBase
  • cytosol Source: Reactome
  • nucleus Source: AgBase
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003931401 – 299Myeloid differentiation primary response protein MyD88Add BLAST299

Proteomic databases

PaxDbiA5HNF6.

Expressioni

Tissue specificityi

Expressed in spleen, liver, kidney, bursa of Fabricius, lung and brain (at protein level). Expressed in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus, bursa of Fabricius, muscle and lung.2 Publications

Gene expression databases

BgeeiENSGALG00000005947.
ExpressionAtlasiA5HNF6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009551.

Structurei

3D structure databases

ProteinModelPortaliA5HNF6.
SMRiA5HNF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 113DeathPROSITE-ProRule annotationAdd BLAST80
Domaini162 – 299TIRPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 158Intermediate domainBy similarityAdd BLAST45

Domaini

The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.By similarity

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 1 TIR domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIN8. Eukaryota.
ENOG410ZIY0. LUCA.
GeneTreeiENSGT00510000048324.
HOVERGENiHBG052547.
InParanoidiA5HNF6.
KOiK04729.
PhylomeDBiA5HNF6.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR017281. Myelin_different_resp_MyD88.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF13676. TIR_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037756. MyD88. 1 hit.
SMARTiSM00005. DEATH. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5HNF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPVGAGS APGPEPADLH SVPMVALNYG VRRRLGLYLN PRAATAADWT
60 70 80 90 100
ALAEKLGHDY LEIRRLEALP DPTAALLEEW QSRCPGGATV GQLLELLRQL
110 120 130 140 150
GRHDVLLELG GSVEEDCKKY LRRKQQEAEQ PLQVPAVDSS VPKTSELMGI
160 170 180 190 200
TTRDDPYGHG TEMFDAFICY CQKDLQFVQE MIRELEQTEF KLKLCVFDRD
210 220 230 240 250
VLPGTCVWSI SGELIERRCR RMVVVISDDY LESDECDFQT KFALSLSPGA
260 270 280 290
RLKRLIPVKC KTMKNEFPSI LRFITICDYT NPCTKKWFWT RLAKSLLLP
Length:299
Mass (Da):33,781
Last modified:June 12, 2007 - v1
Checksum:i62138CF9E06B02B3
GO

Sequence cautioni

The sequence ABJ98316 differs from that shown. Reason: Frameshift at position 287.Curated
The sequence CAH65274 differs from that shown. Reason: Frameshift at position 287.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF011109 mRNA. Translation: ABJ98316.1. Frameshift.
EF544486 mRNA. Translation: ABQ17966.1.
AJ851640 mRNA. Translation: CAH65274.1. Frameshift.
RefSeqiNP_001026133.2. NM_001030962.3.
UniGeneiGga.17397.

Genome annotation databases

EnsembliENSGALT00000044477; ENSGALP00000042597; ENSGALG00000005947.
GeneIDi420420.
KEGGigga:420420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF011109 mRNA. Translation: ABJ98316.1. Frameshift.
EF544486 mRNA. Translation: ABQ17966.1.
AJ851640 mRNA. Translation: CAH65274.1. Frameshift.
RefSeqiNP_001026133.2. NM_001030962.3.
UniGeneiGga.17397.

3D structure databases

ProteinModelPortaliA5HNF6.
SMRiA5HNF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009551.

Proteomic databases

PaxDbiA5HNF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000044477; ENSGALP00000042597; ENSGALG00000005947.
GeneIDi420420.
KEGGigga:420420.

Organism-specific databases

CTDi4615.

Phylogenomic databases

eggNOGiENOG410IIN8. Eukaryota.
ENOG410ZIY0. LUCA.
GeneTreeiENSGT00510000048324.
HOVERGENiHBG052547.
InParanoidiA5HNF6.
KOiK04729.
PhylomeDBiA5HNF6.

Enzyme and pathway databases

ReactomeiR-GGA-209543. p75NTR recruits signalling complexes.
R-GGA-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-GGA-433822. NFkB and MAPK activation mediated by TRAF6.
R-GGA-446652. Interleukin-1 signaling.
R-GGA-451477. MyD88-dependent cascade initiated on endosome membrane.
R-GGA-451514. MyD88:TIRAP-dependent cascade initiated on plasma membrane.
R-GGA-573298. NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation.
R-GGA-933541. TRAF6 mediated IRF7 activation.
R-GGA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
R-GGA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-GGA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-GGA-975155. MyD88 dependent cascade initiated on endosome.
R-GGA-977240. MyD88 cascade initiated on plasma membrane.

Miscellaneous databases

PROiA5HNF6.

Gene expression databases

BgeeiENSGALG00000005947.
ExpressionAtlasiA5HNF6. baseline and differential.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR017281. Myelin_different_resp_MyD88.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF13676. TIR_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037756. MyD88. 1 hit.
SMARTiSM00005. DEATH. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYD88_CHICK
AccessioniPrimary (citable) accession number: A5HNF6
Secondary accession number(s): A0FIQ0, Q5F3L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.