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Protein

Amyloid protein-binding protein 2

Gene

Appbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid protein-binding protein 2
Alternative name(s):
Amyloid beta precursor protein-binding protein 2
Short name:
APP-BP2
Gene namesi
Name:Appbp2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1306488. Appbp2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytoskeleton By similarity
  • Membrane Curated; Peripheral membrane protein Curated

  • Note: Associated with membranes and microtubules.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Amyloid protein-binding protein 2PRO_0000296299Add
BLAST

Post-translational modificationi

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.By similarity

Proteomic databases

PaxDbiA5HK05.

PTM databases

iPTMnetiA5HK05.
PhosphoSiteiA5HK05.

Expressioni

Gene expression databases

ExpressionAtlasiA5HK05. baseline and differential.
GenevisibleiA5HK05. RN.

Interactioni

Subunit structurei

Binds APP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032753.

Structurei

3D structure databases

ProteinModelPortaliA5HK05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 8334TPR 1Sequence analysisAdd
BLAST
Repeati120 – 15334TPR 2Sequence analysisAdd
BLAST
Repeati206 – 23934TPR 3Sequence analysisAdd
BLAST
Repeati288 – 32134TPR 4Sequence analysisAdd
BLAST
Repeati333 – 36735TPR 5Sequence analysisAdd
BLAST
Repeati429 – 46234TPR 6Sequence analysisAdd
BLAST
Repeati471 – 50535TPR 7Sequence analysisAdd
BLAST
Repeati514 – 54734TPR 8Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
HOGENOMiHOG000007799.
HOVERGENiHBG050527.
InParanoidiA5HK05.
OMAiHYDEAYR.
OrthoDBiEOG790G0N.
PhylomeDBiA5HK05.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5HK05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ
60 70 80 90 100
GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS
110 120 130 140 150
FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC
160 170 180 190 200
TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG
210 220 230 240 250
QQANRAALYG ELCALLFAKS HYDEAYKWCV EAMKEITSGL PVKVVVDVLR
260 270 280 290 300
QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
310 320 330 340 350
VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF
360 370 380 390 400
DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ
410 420 430 440 450
RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE
460 470 480 490 500
MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA
510 520 530 540 550
IGKKLFGEGY SGLEYDYRGL IKLYNSTGNY EKVFEYHNVL SNWNRLRDRQ
560 570 580
YSVTDALEDV NSSPQSTEEV VQSFLMSQNV EGPSC
Length:585
Mass (Da):66,902
Last modified:June 12, 2007 - v1
Checksum:i8C8985EAF844CB62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF535262 mRNA. Translation: ABQ00241.1.
BC091285 mRNA. Translation: AAH91285.1.
RefSeqiNP_001094439.1. NM_001100969.1.
UniGeneiRn.104856.

Genome annotation databases

EnsembliENSRNOT00000033684; ENSRNOP00000032753; ENSRNOG00000027654.
GeneIDi303396.
KEGGirno:303396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF535262 mRNA. Translation: ABQ00241.1.
BC091285 mRNA. Translation: AAH91285.1.
RefSeqiNP_001094439.1. NM_001100969.1.
UniGeneiRn.104856.

3D structure databases

ProteinModelPortaliA5HK05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032753.

PTM databases

iPTMnetiA5HK05.
PhosphoSiteiA5HK05.

Proteomic databases

PaxDbiA5HK05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033684; ENSRNOP00000032753; ENSRNOG00000027654.
GeneIDi303396.
KEGGirno:303396.

Organism-specific databases

CTDi10513.
RGDi1306488. Appbp2.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
HOGENOMiHOG000007799.
HOVERGENiHBG050527.
InParanoidiA5HK05.
OMAiHYDEAYR.
OrthoDBiEOG790G0N.
PhylomeDBiA5HK05.
TreeFamiTF314010.

Miscellaneous databases

NextBioi651286.
PROiA5HK05.

Gene expression databases

ExpressionAtlasiA5HK05. baseline and differential.
GenevisibleiA5HK05. RN.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The neuronal glycine transporter GlyT2 interacts with subunits of microtubule-dependent motor proteins."
    Scholze P., Armsen W., Eulenburg V., Horiuchi M., Zeitelhofer M., Tuebing F., Dahm R., Betz H.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 52-585.
    Tissue: OvaryImported.

Entry informationi

Entry nameiAPBP2_RAT
AccessioniPrimary (citable) accession number: A5HK05
Secondary accession number(s): Q5BJX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: May 11, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.