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Protein
Submitted name:

Protein Tlr8

Gene

Tlr8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: Ensembl
  • double-stranded RNA binding Source: Ensembl
  • drug binding Source: RGD
  • single-stranded RNA binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiR-RNO-1679131. Trafficking and processing of endosomal TLR.
R-RNO-168181. Toll Like Receptor 7/8 (TLR7/8) Cascade.
R-RNO-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-RNO-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-RNO-975155. MyD88 dependent cascade initiated on endosome.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Tlr8Imported
Submitted name:
Toll-like receptor 8Imported
Gene namesi
Name:Tlr8Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1590327. Tlr8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei817 – 84024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 10291009Sequence analysisPRO_5007184991Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066040.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini866 – 1013148TIRInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOVERGENiHBG018601.
KOiK10170.
OMAiTHHLEFI.
OrthoDBiEOG7VB2DM.
PhylomeDBiA5H300.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027175. TLR8.
[Graphical view]
PANTHERiPTHR24365:SF296. PTHR24365:SF296. 4 hits.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 22 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5H300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPQSWILTC FCLLSSGTSA VFLKGNFSRS YPCDEKRHNA LVTAECNHRQ
60 70 80 90 100
LHEVPQTIGK YVTDVDLSDN TIMHITNESF QKFRNLTKIN LNHNAKQQHP
110 120 130 140 150
NENKNGMNIT EGAFLSLRNL TELLLEDNQL YTIPAGLPES LKELSLIQNN
160 170 180 190 200
IFQVTKNNTF GLRNLERLYL GWNCYFKCNQ IFKVEDGAFN NLINLKLLSL
210 220 230 240 250
SFNNLFSVPP KLPSSLSKLF LSNAKISTIT QEDFKGLEHL ILLDLSGNCP
260 270 280 290 300
RCFNAPFPCE SCNLSASIRI HPLAFQNLTQ LRFLNLSSTS LRTIPSTWFD
310 320 330 340 350
NLTNLKELHL EFNYLVQEIA SGAFLTKLPS LQTLDLSFNF IHKEYLQYIT
360 370 380 390 400
ISPNFSMLRS LRKLHLKGYV FRELKKEHFK PLQNLPNLTT INLGINFIEK
410 420 430 440 450
IDFKAFQDFP NLKVIYLSGN RIASVIDGTD HSSWRNRLRK PLSTDYDEFD
460 470 480 490 500
PHMNFYHSTE PLIKPQCTTY GKALDLSLNN IFVIGKSQFE GFQDIACLNL
510 520 530 540 550
SFNANGQVLN GTEFSSMPHI KYLDLTNNRL DFDDNQTFSD LHDLEVLDLS
560 570 580 590 600
HNAHYFSIAG VTHRLGFIQN LIKLKVLNLS HNGIYTLTDE YKLQSKSLKE
610 620 630 640 650
LVFSGNRLDR LWNANDGKYW SIFTSLETLT RLDLSYNNLQ QIPNEAFLNL
660 670 680 690 700
PQSLQELHIN DNRLRFFNWT LLQYFPHLHV LDLGRNELYF LTNCLSKFTH
710 720 730 740 750
SLKTLLLNHN HFSHLPAGFL SEARNLVYLD LSFNTIKMIN KSSLQTETKT
760 770 780 790 800
NLSVLDLQGN HFDCTCDISD FRSWLEENPH VRIPRLVDVI CSNPGDQRWK
810 820 830 840 850
SVMSLDLTTC VSDTTAAILF FFTFLTTSTV LLAALVHHLF YWDVWFIYHM
860 870 880 890 900
CSAKLRGYRS SSTSQTFYDA YISYDTKDAS VTDWVINELR YHLEESEDKS
910 920 930 940 950
VLLCLEERDW DPGLPIIDNL MQSINQSKKT IFVLTKKYAK SWNFKTAFYL
960 970 980 990 1000
ALQRLMDENM DVIIFILLEP VLQYSQYLRL RQRICKSSIL QWPNNPKAEN
1010 1020
LFWQSLKNVV LTENDSRYDN LYIDSIRQY
Length:1,029
Mass (Da):119,272
Last modified:June 12, 2007 - v1
Checksum:iC9FAADD3F743F9EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07037696 Genomic DNA. No translation available.
AABR07037697 Genomic DNA. No translation available.
AABR07037698 Genomic DNA. No translation available.
EF032638 mRNA. Translation: ABM92444.1.
RefSeqiNP_001094479.1. NM_001101009.1.
UniGeneiRn.216383.

Genome annotation databases

EnsembliENSRNOT00000073535; ENSRNOP00000066040; ENSRNOG00000045992.
GeneIDi684440.
KEGGirno:684440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07037696 Genomic DNA. No translation available.
AABR07037697 Genomic DNA. No translation available.
AABR07037698 Genomic DNA. No translation available.
EF032638 mRNA. Translation: ABM92444.1.
RefSeqiNP_001094479.1. NM_001101009.1.
UniGeneiRn.216383.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073535; ENSRNOP00000066040; ENSRNOG00000045992.
GeneIDi684440.
KEGGirno:684440.

Organism-specific databases

CTDi51311.
RGDi1590327. Tlr8.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOVERGENiHBG018601.
KOiK10170.
OMAiTHHLEFI.
OrthoDBiEOG7VB2DM.
PhylomeDBiA5H300.

Enzyme and pathway databases

ReactomeiR-RNO-1679131. Trafficking and processing of endosomal TLR.
R-RNO-168181. Toll Like Receptor 7/8 (TLR7/8) Cascade.
R-RNO-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-RNO-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-RNO-975155. MyD88 dependent cascade initiated on endosome.

Miscellaneous databases

PROiA5H300.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027175. TLR8.
[Graphical view]
PANTHERiPTHR24365:SF296. PTHR24365:SF296. 4 hits.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 22 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. "Rattus norvegicus toll-like receptor 8 (TLR8) mRNA."
    Chuang T.-H.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: SpleenImported.
  3. "A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition."
    Liu J., Xu C., Hsu L.C., Luo Y., Xiang R., Chuang T.H.
    Mol. Immunol. 47:1083-1090(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: SpleenImported.
  4. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiA5H300_RAT
AccessioniPrimary (citable) accession number: A5H300
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.