Unreviewed, UniProtKB/TrEMBL A5H1P7 (A5H1P7_HUMAN)

Names and origin

Protein names

Submitted name:
    Potassium voltage-gated channel subfamily H member 2 EMBL ABQ01243.1
Submitted name:
    Potassium voltage-gated channel, subfamily H (Eag-related), member 2, isoform CRA_b EMBL EAW54072.1

Gene names

Name:	KCNH2 EMBL ABQ01243.1
ORF Names:	hCG_18699 EMBL EAW54072.1

Organism

Homo sapiens (Human) EMBL ABQ01243.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Sequence similarities

Contains 1 cyclic nucleotide-binding domain. Spearmint SPM000595

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0 Spearmint SPM003938
Molecular function	Ionic channel RuleBase RU003378V0 Spearmint SPM003938
Gene Ontology (GO)
Biological process	potassium ion transport Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	two-component sensor activity Inferred from electronic annotation. Source: InterPro voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5H1P7-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: D03BD4F657641FBA	FASTA	1,159	126,655
	10 20 30 40 50 60 MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE LCGYSRAEVM 70 80 90 100 110 120 QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR KDGSCFLCLV DVVPVKNEDG 130 140 150 160 170 180 AVIMFILNFE VVMEKDMVGS PAHDTNHRGP PTSWLAPGRA KTFRLKLPAL LALTARESSV 190 200 210 220 230 240 RSGGAGGAGA PGAVVVDVDL TPAAPSSESL ALDEVTAMDN HVAGLGPAEE RRALVGPGSP 250 260 270 280 290 300 PRSAPGQLPS PRAHSLNPDA SGSSCSLART RSRESCASVR RASSADDIEA MRAGVLPPPP 310 320 330 340 350 360 RHASTGAMHP LRSGLLNSTS DSDLVRYRTI SKIPQITLNF VDLKGDPFLA SPTSDREIIA 370 380 390 400 410 420 PKIKERTHNV TEKVTQVLSL GADVLPEYKL QAPRIHRWTI LHYSPFKAVW DWLILLLVIY 430 440 450 460 470 480 TAVFTPYSAA FLLKETEEGP PATECGYACQ PLAVVDLIVD IMFIVDILIN FRTTYVNANE 490 500 510 520 530 540 EVVSHPGRIA VHYFKGWFLI DMVAAIPFDL LIFGSGSEEL IGLLKTARLL RLVRVARKLD 550 560 570 580 590 600 RYSEYGAAVL FLLMCTFALI AHWLACIWYA IGNMEQPHMD SRIGWLHNLG DQIGKPYNSS 610 620 630 640 650 660 GLGGPSIKDK YVTALYFTFS SLTSVGFGNV SPNTNSEKIF SICVMLIGSL MYASIFGNVS 670 680 690 700 710 720 AIIQRLYSGT ARYHTQMLRV REFIRFHQIP NPLRQRLEEY FQHAWSYTNG IDMNAVLKGF 730 740 750 760 770 780 PECLQADICL HLNRSLLQHC KPFRGATKGC LRALAMKFKT THAPPGDTLV HAGDLLTALY 790 800 810 820 830 840 FISRGSIEIL RGDVVVAILG KNDIFGEPLN LYARPGKSNG DVRALTYCDL HKIHRDDLLE 850 860 870 880 890 900 VLDMYPEFSD HFWSSLEITF NLRDTNMIPG SPGSTELEGG FSRQRKRKLS FRRRTDKDTE 910 920 930 940 950 960 QPGEVSALGP GRAGAGPSSR GRPGGPWGES PSSGPSSPES SEDEGPGRSS SPLRLVPFSS 970 980 990 1000 1010 1020 PRPPGEPPGG EPLMEDCEKS SDTCNPLSGA FSGVSNIFSF WGDSRGRQYQ ELPRCPAPTP 1030 1040 1050 1060 1070 1080 SLLNIPLSSP GRRPRGDVES RLDALQRQLN RLETRLSADM ATVLQLLQRQ MTLVPPAYSA 1090 1100 1110 1120 1130 1140 VTTPGPGPTS TSPLLPVSPL PTLTLDSLSQ VSQFMACEEL PPGAPELPQE GPTRRLSLPG 1150 QLGALTSQPL HRHGSDPGS

References

[1]	Stockwell T.B., Busam D.A., Ferriera S.M., Brownley A.N., Strausberg R.L., Kirkness E.F., Rogers Y.-H., Levy S. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ784808 Genomic DNA. Translation: ABQ01243.1. CH471173 Genomic DNA. Translation: EAW54072.1.
IPI	IPI00029662.
RefSeq	NP_000229.1.
UniGene	Hs.647099
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A5H1P7.
Genome annotation databases
Ensembl	ENSG00000055118. Homo sapiens. [Contig view]
GeneID	3757.
KEGG	hsa:3757.
Organism-specific databases
HGNC	HGNC:6251. KCNH2.
GenAtlas	Search...
Phylogenomic databases
OMA	A5H1P7. ARDTNHR.
Gene expression databases
Bgee	A5H1P7.
Family and domain databases
InterPro	IPR000595. cNMP_bd. IPR005821. Ion_trans. IPR003938. K_chnl_volt-dep_EAG/ELK/ERG. IPR003967. K_chnl_volt-dep_ERG. IPR001610. PAC. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR013767. PAS_fold. [Graphical view]
Pfam	PF00027. cNMP_binding. 1 hit. PF00520. Ion_trans. 1 hit. PF00989. PAS. 1 hit. [Graphical view]
PRINTS	PR01463. EAGCHANLFMLY. PR01470. ERGCHANNEL.
SMART	SM00100. cNMP. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
PROSITE	PS50042. CNMP_BINDING_3. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	14717.

Entry information

Entry name

A5H1P7_HUMAN

Accession

Primary (citable) accession number: A5H1P7

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)