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A5GZX3

- A5GZX3_MOUSE

UniProt

A5GZX3 - A5GZX3_MOUSE

Protein

Lactoylglutathione lyase

Gene

Glo1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.UniRule annotation

    Catalytic activityi

    (R)-S-lactoylglutathione = glutathione + methylglyoxal.UniRule annotation

    Cofactori

    Zinc.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lactoylglutathione lyase activity Source: MGI
    2. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. carbohydrate metabolic process Source: Ensembl
    2. glutathione metabolic process Source: Ensembl
    3. methylglyoxal metabolic process Source: Ensembl
    4. negative regulation of apoptotic process Source: Ensembl
    5. regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    LyaseUniRule annotationImported

    Keywords - Ligandi

    Metal-bindingUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00619; UER00675.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactoylglutathione lyaseUniRule annotation (EC:4.4.1.5UniRule annotation)
    Alternative name(s):
    Glyoxalase IUniRule annotation
    Gene namesi
    Name:Glo1Imported
    ORF Names:mCG_50439Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95742. Glo1.

    Expressioni

    Gene expression databases

    GenevestigatoriA5GZX3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glyoxalase I family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG025852.
    InParanoidiA5GZX3.
    KOiK01759.
    OMAiWALSRKA.

    Family and domain databases

    Gene3Di3.10.180.10. 1 hit.
    InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    IPR004361. Glyoxalase_1.
    IPR018146. Glyoxalase_1_CS.
    [Graphical view]
    PfamiPF00903. Glyoxalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF54593. SSF54593. 1 hit.
    TIGRFAMsiTIGR00068. glyox_I. 1 hit.
    PROSITEiPS00934. GLYOXALASE_I_1. 1 hit.
    PS00935. GLYOXALASE_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5GZX3-1 [UniParc]FASTAAdd to Basket

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    MAEPQPASSG LTDETAFSCC SDPDPSTKDF LLQQTMLRIK DPKKSLDFYT    50
    RVLGLTLLQK LDFPAMKFSL YFLAYEDKND IPKDKSEKTA WTFSRKATLE 100
    LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV 150
    KKPDDGKMKG LAFIQDPDGY WIEILNPNKI ATII 184
    Length:184
    Mass (Da):20,810
    Last modified:June 12, 2007 - v1
    Checksum:iF6B5667A65454D18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ487161 mRNA. Translation: ABF48483.1.
    DQ487162 mRNA. Translation: ABF48484.1.
    CH466542 Genomic DNA. Translation: EDL08651.1.
    RefSeqiNP_001107032.1. NM_001113560.1.
    NP_079650.3. NM_025374.3.
    UniGeneiMm.261984.

    Genome annotation databases

    GeneIDi109801.
    KEGGimmu:109801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ487161 mRNA. Translation: ABF48483.1 .
    DQ487162 mRNA. Translation: ABF48484.1 .
    CH466542 Genomic DNA. Translation: EDL08651.1 .
    RefSeqi NP_001107032.1. NM_001113560.1.
    NP_079650.3. NM_025374.3.
    UniGenei Mm.261984.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 109801.
    KEGGi mmu:109801.

    Organism-specific databases

    CTDi 2739.
    MGIi MGI:95742. Glo1.

    Phylogenomic databases

    HOVERGENi HBG025852.
    InParanoidi A5GZX3.
    KOi K01759.
    OMAi WALSRKA.

    Enzyme and pathway databases

    UniPathwayi UPA00619 ; UER00675 .

    Miscellaneous databases

    ChiTaRSi GLO1. mouse.
    NextBioi 362781.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori A5GZX3.

    Family and domain databases

    Gene3Di 3.10.180.10. 1 hit.
    InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    IPR004361. Glyoxalase_1.
    IPR018146. Glyoxalase_1_CS.
    [Graphical view ]
    Pfami PF00903. Glyoxalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54593. SSF54593. 1 hit.
    TIGRFAMsi TIGR00068. glyox_I. 1 hit.
    PROSITEi PS00934. GLYOXALASE_I_1. 1 hit.
    PS00935. GLYOXALASE_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. "Verification of quantitative trait loci for increased carbohydrate and total energy intake in a congenic segment on mouse chromosome 17."
      Kumar G.K., Poole A.C., Volaufova J., York B., Zuberi A., Smith Richards B.K.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and CAST/EiImported.

    Entry informationi

    Entry nameiA5GZX3_MOUSE
    AccessioniPrimary (citable) accession number: A5GZX3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)