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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SynRCC307_2390
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001115 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000045622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi316278.SynRCC307_2390.

Structurei

3D structure databases

ProteinModelPortaliA5GWN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GWN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGFVQRHL GPSPAEQAQM LQRLGCRDLE QLLQECVPAE ILIDADQARD
60 70 80 90 100
ALPQECDERQ ALRELEQRAA ANTVLRNLIG LGYYDTATPA LIQRHVLENP
110 120 130 140 150
AWYTAYTPYQ AEIAQGRLEA LLNFQTLISE LTGLPIANAS LLDEATAAAE
160 170 180 190 200
AMTLAYGACR LKQARRFHVQ ADLFPQTLAV LQTRAEPLGI ELVVADPAAM
210 220 230 240 250
DFGDDSFGLL LQLPTASGAC PDPTEVIARA KAADVLVIAA VDPLAQVLMP
260 270 280 290 300
PVAQLGVQIA VGSAQRFGVP LGFGGPHAAF FATTEAYKRQ IPGRLVGMSR
310 320 330 340 350
DAAGEPALRL ALQTREQHIR RDKATSNICT AQVLLAVMAG FYAVHHGPDG
360 370 380 390 400
LTAIARRVQR LTAALAAGLQ QLGLDVAAAP AFDTLRLRLD QPNGWIERLE
410 420 430 440 450
AAGFNLLPLP DGAGISLDEC SDEAEVQALL ECFAAGCGRT APAISELLAA
460 470 480 490 500
TPQAKSVGEL PVRPAGWLPQ AVFQLYRSET ELLRYIQRLV SKDFSLVHGM
510 520 530 540 550
IPLGSCTMKL NAAAELQPVS WAAFNRLHPF VPAAQRQGYD QLINELEAWL
560 570 580 590 600
ATITGFAAVS LQPNAGSQGE YAGLLVIRAW HRQRGEGHRN ICLIPTSAHG
610 620 630 640 650
TNPASAVMAG MQVVAVQCDE AGNIDQADLA AKAEQHADQL AALMVTYPST
660 670 680 690 700
HGVFEQGISD ICALIHRHGG QVYLDGANLN AQVGVCQPGR FGADVCHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPIAV AAHLAPFLPG HPLVPCGGEQ AIGPVSAAPW
760 770 780 790 800
GSASILPISW MYIRLMGGAG LRQATAVALL AANDLAERLE PHFPVLYRGA
810 820 830 840 850
NGRVAHECIL DLRPLKRSAG LEVDDLAKRL MDYGFHAPTV SWPVAGTVMV
860 870 880 890 900
EPTESESLLE LDRFVEAMMA IRAEAAAIEA GLCDRDDNPL RRAPHTLAAV
910 920 930 940 950
TADVWERPYS REQAAYPVQG LRSNKLWPAV SRIDNAFGDR NLICTCPSVE

ELARAAG
Length:957
Mass (Da):102,294
Last modified:June 11, 2007 - v1
Checksum:iE1DB8F28146EE3F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA. Translation: CAK29293.1.
RefSeqiWP_011936802.1. NC_009482.1.
YP_001228646.1. NC_009482.1.

Genome annotation databases

EnsemblBacteriaiCAK29293; CAK29293; SynRCC307_2390.
GeneIDi5156384.
KEGGisyr:SynRCC307_2390.
PATRICi23825733. VBISynSp108374_2401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA. Translation: CAK29293.1.
RefSeqiWP_011936802.1. NC_009482.1.
YP_001228646.1. NC_009482.1.

3D structure databases

ProteinModelPortaliA5GWN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316278.SynRCC307_2390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK29293; CAK29293; SynRCC307_2390.
GeneIDi5156384.
KEGGisyr:SynRCC307_2390.
PATRICi23825733. VBISynSp108374_2401.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Genoscope
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCC307.

Entry informationi

Entry nameiGCSP_SYNR3
AccessioniPrimary (citable) accession number: A5GWN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 14, 2008
Last sequence update: June 11, 2007
Last modified: January 6, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.