Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A5GWN4

- GCSP_SYNR3

UniProt

A5GWN4 - GCSP_SYNR3

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:SynRCC307_2390
    OrganismiSynechococcus sp. (strain RCC307)
    Taxonomic identifieri316278 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001115: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000045622Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi316278.SynRCC307_2390.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GWN4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5GWN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAGFVQRHL GPSPAEQAQM LQRLGCRDLE QLLQECVPAE ILIDADQARD    50
    ALPQECDERQ ALRELEQRAA ANTVLRNLIG LGYYDTATPA LIQRHVLENP 100
    AWYTAYTPYQ AEIAQGRLEA LLNFQTLISE LTGLPIANAS LLDEATAAAE 150
    AMTLAYGACR LKQARRFHVQ ADLFPQTLAV LQTRAEPLGI ELVVADPAAM 200
    DFGDDSFGLL LQLPTASGAC PDPTEVIARA KAADVLVIAA VDPLAQVLMP 250
    PVAQLGVQIA VGSAQRFGVP LGFGGPHAAF FATTEAYKRQ IPGRLVGMSR 300
    DAAGEPALRL ALQTREQHIR RDKATSNICT AQVLLAVMAG FYAVHHGPDG 350
    LTAIARRVQR LTAALAAGLQ QLGLDVAAAP AFDTLRLRLD QPNGWIERLE 400
    AAGFNLLPLP DGAGISLDEC SDEAEVQALL ECFAAGCGRT APAISELLAA 450
    TPQAKSVGEL PVRPAGWLPQ AVFQLYRSET ELLRYIQRLV SKDFSLVHGM 500
    IPLGSCTMKL NAAAELQPVS WAAFNRLHPF VPAAQRQGYD QLINELEAWL 550
    ATITGFAAVS LQPNAGSQGE YAGLLVIRAW HRQRGEGHRN ICLIPTSAHG 600
    TNPASAVMAG MQVVAVQCDE AGNIDQADLA AKAEQHADQL AALMVTYPST 650
    HGVFEQGISD ICALIHRHGG QVYLDGANLN AQVGVCQPGR FGADVCHLNL 700
    HKTFCIPHGG GGPGVGPIAV AAHLAPFLPG HPLVPCGGEQ AIGPVSAAPW 750
    GSASILPISW MYIRLMGGAG LRQATAVALL AANDLAERLE PHFPVLYRGA 800
    NGRVAHECIL DLRPLKRSAG LEVDDLAKRL MDYGFHAPTV SWPVAGTVMV 850
    EPTESESLLE LDRFVEAMMA IRAEAAAIEA GLCDRDDNPL RRAPHTLAAV 900
    TADVWERPYS REQAAYPVQG LRSNKLWPAV SRIDNAFGDR NLICTCPSVE 950
    ELARAAG 957
    Length:957
    Mass (Da):102,294
    Last modified:June 12, 2007 - v1
    Checksum:iE1DB8F28146EE3F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT978603 Genomic DNA. Translation: CAK29293.1.
    RefSeqiWP_011936802.1. NC_009482.1.
    YP_001228646.1. NC_009482.1.

    Genome annotation databases

    EnsemblBacteriaiCAK29293; CAK29293; SynRCC307_2390.
    GeneIDi5156384.
    KEGGisyr:SynRCC307_2390.
    PATRICi23825733. VBISynSp108374_2401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT978603 Genomic DNA. Translation: CAK29293.1 .
    RefSeqi WP_011936802.1. NC_009482.1.
    YP_001228646.1. NC_009482.1.

    3D structure databases

    ProteinModelPortali A5GWN4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316278.SynRCC307_2390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK29293 ; CAK29293 ; SynRCC307_2390 .
    GeneIDi 5156384.
    KEGGi syr:SynRCC307_2390.
    PATRICi 23825733. VBISynSp108374_2401.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RCC307.

    Entry informationi

    Entry nameiGCSP_SYNR3
    AccessioniPrimary (citable) accession number: A5GWN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3