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A5GWN4

- GCSP_SYNR3

UniProt

A5GWN4 - GCSP_SYNR3

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, SynRCC307_2390
Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:SynRCC307_2390
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001115: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi316278.SynRCC307_2390.

Structurei

3D structure databases

ProteinModelPortaliA5GWN4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GWN4-1 [UniParc]FASTAAdd to Basket

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MSAGFVQRHL GPSPAEQAQM LQRLGCRDLE QLLQECVPAE ILIDADQARD    50
ALPQECDERQ ALRELEQRAA ANTVLRNLIG LGYYDTATPA LIQRHVLENP 100
AWYTAYTPYQ AEIAQGRLEA LLNFQTLISE LTGLPIANAS LLDEATAAAE 150
AMTLAYGACR LKQARRFHVQ ADLFPQTLAV LQTRAEPLGI ELVVADPAAM 200
DFGDDSFGLL LQLPTASGAC PDPTEVIARA KAADVLVIAA VDPLAQVLMP 250
PVAQLGVQIA VGSAQRFGVP LGFGGPHAAF FATTEAYKRQ IPGRLVGMSR 300
DAAGEPALRL ALQTREQHIR RDKATSNICT AQVLLAVMAG FYAVHHGPDG 350
LTAIARRVQR LTAALAAGLQ QLGLDVAAAP AFDTLRLRLD QPNGWIERLE 400
AAGFNLLPLP DGAGISLDEC SDEAEVQALL ECFAAGCGRT APAISELLAA 450
TPQAKSVGEL PVRPAGWLPQ AVFQLYRSET ELLRYIQRLV SKDFSLVHGM 500
IPLGSCTMKL NAAAELQPVS WAAFNRLHPF VPAAQRQGYD QLINELEAWL 550
ATITGFAAVS LQPNAGSQGE YAGLLVIRAW HRQRGEGHRN ICLIPTSAHG 600
TNPASAVMAG MQVVAVQCDE AGNIDQADLA AKAEQHADQL AALMVTYPST 650
HGVFEQGISD ICALIHRHGG QVYLDGANLN AQVGVCQPGR FGADVCHLNL 700
HKTFCIPHGG GGPGVGPIAV AAHLAPFLPG HPLVPCGGEQ AIGPVSAAPW 750
GSASILPISW MYIRLMGGAG LRQATAVALL AANDLAERLE PHFPVLYRGA 800
NGRVAHECIL DLRPLKRSAG LEVDDLAKRL MDYGFHAPTV SWPVAGTVMV 850
EPTESESLLE LDRFVEAMMA IRAEAAAIEA GLCDRDDNPL RRAPHTLAAV 900
TADVWERPYS REQAAYPVQG LRSNKLWPAV SRIDNAFGDR NLICTCPSVE 950
ELARAAG 957
Length:957
Mass (Da):102,294
Last modified:June 12, 2007 - v1
Checksum:iE1DB8F28146EE3F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK29293.1.
RefSeqiWP_011936802.1. NC_009482.1.
YP_001228646.1. NC_009482.1.

Genome annotation databases

EnsemblBacteriaiCAK29293; CAK29293; SynRCC307_2390.
GeneIDi5156384.
KEGGisyr:SynRCC307_2390.
PATRICi23825733. VBISynSp108374_2401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK29293.1 .
RefSeqi WP_011936802.1. NC_009482.1.
YP_001228646.1. NC_009482.1.

3D structure databases

ProteinModelPortali A5GWN4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316278.SynRCC307_2390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK29293 ; CAK29293 ; SynRCC307_2390 .
GeneIDi 5156384.
KEGGi syr:SynRCC307_2390.
PATRICi 23825733. VBISynSp108374_2401.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCC307.

Entry informationi

Entry nameiGCSP_SYNR3
AccessioniPrimary (citable) accession number: A5GWN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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