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A5GWN4 (GCSP_SYNR3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:SynRCC307_2390
OrganismSynechococcus sp. (strain RCC307) [Complete proteome] [HAMAP]
Taxonomic identifier316278 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045622

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A5GWN4 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: E1DB8F28146EE3F4

FASTA957102,294
        10         20         30         40         50         60 
MSAGFVQRHL GPSPAEQAQM LQRLGCRDLE QLLQECVPAE ILIDADQARD ALPQECDERQ 

        70         80         90        100        110        120 
ALRELEQRAA ANTVLRNLIG LGYYDTATPA LIQRHVLENP AWYTAYTPYQ AEIAQGRLEA 

       130        140        150        160        170        180 
LLNFQTLISE LTGLPIANAS LLDEATAAAE AMTLAYGACR LKQARRFHVQ ADLFPQTLAV 

       190        200        210        220        230        240 
LQTRAEPLGI ELVVADPAAM DFGDDSFGLL LQLPTASGAC PDPTEVIARA KAADVLVIAA 

       250        260        270        280        290        300 
VDPLAQVLMP PVAQLGVQIA VGSAQRFGVP LGFGGPHAAF FATTEAYKRQ IPGRLVGMSR 

       310        320        330        340        350        360 
DAAGEPALRL ALQTREQHIR RDKATSNICT AQVLLAVMAG FYAVHHGPDG LTAIARRVQR 

       370        380        390        400        410        420 
LTAALAAGLQ QLGLDVAAAP AFDTLRLRLD QPNGWIERLE AAGFNLLPLP DGAGISLDEC 

       430        440        450        460        470        480 
SDEAEVQALL ECFAAGCGRT APAISELLAA TPQAKSVGEL PVRPAGWLPQ AVFQLYRSET 

       490        500        510        520        530        540 
ELLRYIQRLV SKDFSLVHGM IPLGSCTMKL NAAAELQPVS WAAFNRLHPF VPAAQRQGYD 

       550        560        570        580        590        600 
QLINELEAWL ATITGFAAVS LQPNAGSQGE YAGLLVIRAW HRQRGEGHRN ICLIPTSAHG 

       610        620        630        640        650        660 
TNPASAVMAG MQVVAVQCDE AGNIDQADLA AKAEQHADQL AALMVTYPST HGVFEQGISD 

       670        680        690        700        710        720 
ICALIHRHGG QVYLDGANLN AQVGVCQPGR FGADVCHLNL HKTFCIPHGG GGPGVGPIAV 

       730        740        750        760        770        780 
AAHLAPFLPG HPLVPCGGEQ AIGPVSAAPW GSASILPISW MYIRLMGGAG LRQATAVALL 

       790        800        810        820        830        840 
AANDLAERLE PHFPVLYRGA NGRVAHECIL DLRPLKRSAG LEVDDLAKRL MDYGFHAPTV 

       850        860        870        880        890        900 
SWPVAGTVMV EPTESESLLE LDRFVEAMMA IRAEAAAIEA GLCDRDDNPL RRAPHTLAAV 

       910        920        930        940        950 
TADVWERPYS REQAAYPVQG LRSNKLWPAV SRIDNAFGDR NLICTCPSVE ELARAAG 

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCC307.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT978603 Genomic DNA. Translation: CAK29293.1.
RefSeqYP_001228646.1. NC_009482.1.

3D structure databases

ProteinModelPortalA5GWN4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316278.SynRCC307_2390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK29293; CAK29293; SynRCC307_2390.
GeneID5156384.
KEGGsyr:SynRCC307_2390.
PATRIC23825733. VBISynSp108374_2401.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SYNR3
AccessionPrimary (citable) accession number: A5GWN4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families