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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSSP316278:G1GJL-2316-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SynRCC307_2390
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001115 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456221 – 957Glycine dehydrogenase (decarboxylating)Add BLAST957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei702N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA5GWN4

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi316278.SynRCC307_2390

Structurei

3D structure databases

ProteinModelPortaliA5GWN4
SMRiA5GWN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A5GWN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGFVQRHL GPSPAEQAQM LQRLGCRDLE QLLQECVPAE ILIDADQARD
60 70 80 90 100
ALPQECDERQ ALRELEQRAA ANTVLRNLIG LGYYDTATPA LIQRHVLENP
110 120 130 140 150
AWYTAYTPYQ AEIAQGRLEA LLNFQTLISE LTGLPIANAS LLDEATAAAE
160 170 180 190 200
AMTLAYGACR LKQARRFHVQ ADLFPQTLAV LQTRAEPLGI ELVVADPAAM
210 220 230 240 250
DFGDDSFGLL LQLPTASGAC PDPTEVIARA KAADVLVIAA VDPLAQVLMP
260 270 280 290 300
PVAQLGVQIA VGSAQRFGVP LGFGGPHAAF FATTEAYKRQ IPGRLVGMSR
310 320 330 340 350
DAAGEPALRL ALQTREQHIR RDKATSNICT AQVLLAVMAG FYAVHHGPDG
360 370 380 390 400
LTAIARRVQR LTAALAAGLQ QLGLDVAAAP AFDTLRLRLD QPNGWIERLE
410 420 430 440 450
AAGFNLLPLP DGAGISLDEC SDEAEVQALL ECFAAGCGRT APAISELLAA
460 470 480 490 500
TPQAKSVGEL PVRPAGWLPQ AVFQLYRSET ELLRYIQRLV SKDFSLVHGM
510 520 530 540 550
IPLGSCTMKL NAAAELQPVS WAAFNRLHPF VPAAQRQGYD QLINELEAWL
560 570 580 590 600
ATITGFAAVS LQPNAGSQGE YAGLLVIRAW HRQRGEGHRN ICLIPTSAHG
610 620 630 640 650
TNPASAVMAG MQVVAVQCDE AGNIDQADLA AKAEQHADQL AALMVTYPST
660 670 680 690 700
HGVFEQGISD ICALIHRHGG QVYLDGANLN AQVGVCQPGR FGADVCHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPIAV AAHLAPFLPG HPLVPCGGEQ AIGPVSAAPW
760 770 780 790 800
GSASILPISW MYIRLMGGAG LRQATAVALL AANDLAERLE PHFPVLYRGA
810 820 830 840 850
NGRVAHECIL DLRPLKRSAG LEVDDLAKRL MDYGFHAPTV SWPVAGTVMV
860 870 880 890 900
EPTESESLLE LDRFVEAMMA IRAEAAAIEA GLCDRDDNPL RRAPHTLAAV
910 920 930 940 950
TADVWERPYS REQAAYPVQG LRSNKLWPAV SRIDNAFGDR NLICTCPSVE

ELARAAG
Length:957
Mass (Da):102,294
Last modified:June 12, 2007 - v1
Checksum:iE1DB8F28146EE3F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA Translation: CAK29293.1
RefSeqiWP_011936802.1, NC_009482.1

Genome annotation databases

EnsemblBacteriaiCAK29293; CAK29293; SynRCC307_2390
KEGGisyr:SynRCC307_2390

Similar proteinsi

Entry informationi

Entry nameiGCSP_SYNR3
AccessioniPrimary (citable) accession number: A5GWN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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