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A5GVR5

- PUR5_SYNR3

UniProt

A5GVR5 - PUR5_SYNR3

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, SynRCC307_2071
Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:SynRCC307_2071
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001115: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000046480Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316278.SynRCC307_2071.

Structurei

3D structure databases

ProteinModelPortaliA5GVR5.
SMRiA5GVR5. Positions 1-336.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GVR5-1 [UniParc]FASTAAdd to Basket

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MDYKSAGVDV EAGRHFVERI RTSVEATHRP EVLGGLGGFG GLCRLPAGLE    50
KPLLVAGTDG VGTKLELAQE CGRHHGVGID LVAMCANDVI TCGAEPLFFL 100
DYIATGKLSP AAMAEVVEGI ASGCSQSGCS LLGGETAEMP GFYPAGRYDL 150
AGFCVAVVDE PRLIDGQTIQ AGDQLLAIAS SGVHSNGFSL VRRILEANQV 200
PLETSQAALG GRSAAEALLE PTLLYAPLVK ALLQSPELEL RGMAHITGGG 250
LPENLPRPLP QGLAAQIDPG SWQRPALFHW LQELGSVPER DLWHTFNLGI 300
GYVLVLPESS CQQALEVVHN SGFTGWICGE IVVGQGVLGL PAGA 344
Length:344
Mass (Da):35,946
Last modified:June 12, 2007 - v1
Checksum:iF8D0575F9AE320CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK28974.1.
RefSeqiWP_011936485.1. NC_009482.1.
YP_001228327.1. NC_009482.1.

Genome annotation databases

EnsemblBacteriaiCAK28974; CAK28974; SynRCC307_2071.
GeneIDi5157709.
KEGGisyr:SynRCC307_2071.
PATRICi23825075. VBISynSp108374_2081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK28974.1 .
RefSeqi WP_011936485.1. NC_009482.1.
YP_001228327.1. NC_009482.1.

3D structure databases

ProteinModelPortali A5GVR5.
SMRi A5GVR5. Positions 1-336.
ModBasei Search...

Protein-protein interaction databases

STRINGi 316278.SynRCC307_2071.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK28974 ; CAK28974 ; SynRCC307_2071 .
GeneIDi 5157709.
KEGGi syr:SynRCC307_2071.
PATRICi 23825075. VBISynSp108374_2081.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCC307.

Entry informationi

Entry nameiPUR5_SYNR3
AccessioniPrimary (citable) accession number: A5GVR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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