A5GVR5 (PUR5_SYNR3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	SynRCC307_2071

Organism

Synechococcus sp. (strain RCC307) [Complete proteome] [HAMAP]

Taxonomic identifier

316278 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741		PRO_1000046480

Sequences

	Sequence		Length	Mass (Da)
	A5GVR5 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: F8D0575F9AE320CA	FASTA	344	35,946
	10 20 30 40 50 60 MDYKSAGVDV EAGRHFVERI RTSVEATHRP EVLGGLGGFG GLCRLPAGLE KPLLVAGTDG 70 80 90 100 110 120 VGTKLELAQE CGRHHGVGID LVAMCANDVI TCGAEPLFFL DYIATGKLSP AAMAEVVEGI 130 140 150 160 170 180 ASGCSQSGCS LLGGETAEMP GFYPAGRYDL AGFCVAVVDE PRLIDGQTIQ AGDQLLAIAS 190 200 210 220 230 240 SGVHSNGFSL VRRILEANQV PLETSQAALG GRSAAEALLE PTLLYAPLVK ALLQSPELEL 250 260 270 280 290 300 RGMAHITGGG LPENLPRPLP QGLAAQIDPG SWQRPALFHW LQELGSVPER DLWHTFNLGI 310 320 330 340 GYVLVLPESS CQQALEVVHN SGFTGWICGE IVVGQGVLGL PAGA

References

[1]	Genoscope Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RCC307.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT978603 Genomic DNA. Translation: CAK28974.1.
RefSeq	YP_001228327.1. NC_009482.1.
3D structure databases
ProteinModelPortal	A5GVR5.
SMR	A5GVR5. Positions 1-336.
ModBase	Search...
Protein-protein interaction databases
STRING	316278.SynRCC307_2071.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAK28974; CAK28974; SynRCC307_2071.
GeneID	5157709.
KEGG	syr:SynRCC307_2071.
PATRIC	23825075. VBISynSp108374_2081.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HOG000229090.
KO	K01933.
OMA	PRVLPKH.
ProtClustDB	PRK05385.
Enzyme and pathway databases
UniPathway	UPA00074; UER00129.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_SYNR3

Accession

Primary (citable) accession number: A5GVR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program