ID   ACSF_SYNR3              Reviewed;         360 AA.
AC   A5GU20;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   16-JUN-2009, entry version 14.
DE   RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
DE            Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
DE            EC=1.14.13.81;
GN   Name=acsF; OrderedLocusNames=SynRCC307_1476;
OS   Synechococcus sp. (strain RCC307).
OC   Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
OX   NCBI_TaxID=316278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of the isocyclic ring in
CC       chlorophyll biosynthesis. Mediates the cyclase reaction, which
CC       results in the formation of divinylprotochlorophyllide (Pchlide)
CC       characteristic of all chlorophylls from magnesium-protoporphyrin
CC       IX 13-monomethyl ester (MgPMME) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Magnesium-protoporphyrin IX 13-monomethyl
CC       ester + NADPH + O(2) = 13(1)-hydroxy-magnesium-protoporphyrin IX
CC       13-monomethyl ester + NADP(+) + H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-hydroxy-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = 13(1)-oxo-magnesium-
CC       protoporphyrin IX 13-monomethyl ester + NADP(+) + 2 H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-oxo-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = divinylprotochlorophyllide +
CC       NADP(+) + 2 H(2)O.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis (light-
CC       independent).
CC   -!- SIMILARITY: Belongs to the acsF family.
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DR   EMBL; CT978603; CAK28379.1; -; Genomic_DNA.
DR   RefSeq; YP_001227732.1; -.
DR   GeneID; 5157882; -.
DR   GenomeReviews; CT978603_GR; SynRCC307_1476.
DR   KEGG; syr:SynRCC307_1476; -.
DR   OMA; A5GU20; SMSDFGL.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0048529; F:magnesium-protoporphyrin IX monomethyl este...; IEA:HAMAP.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0015979; P:photosynthesis; IEA:HAMAP.
DR   HAMAP; MF_01840; -; 1.
DR   InterPro; IPR008434; AcsF.
DR   InterPro; IPR003251; Rubrerythrin.
DR   Pfam; PF02915; Rubrerythrin; 1.
DR   TIGRFAMs; TIGR02029; AcsF; 1.
PE   3: Inferred from homology;
KW   Chlorophyll biosynthesis; Complete proteome; Iron; Metal-binding;
KW   NADP; Oxidoreductase; Photosynthesis.
FT   CHAIN         1    360       Magnesium-protoporphyrin IX monomethyl
FT                                ester [oxidative] cyclase.
FT                                /FTId=PRO_1000070554.
SQ   SEQUENCE   360 AA;  41621 MW;  0F43C7BBCA1E07DA CRC64;
     MVPPTAIAEA SRSGGEPAIK DPVKDTILTP RFYTTDFEAM AAMDLRPNQE ELEAICEEFR
     KDYNRHHFVR NEAFDGAADK LDPETRRVFV EFLEQSCTSE FSGFLLYKEL SRRIKQKNPL
     LAECFAHMAR DEARHAGFLN KAMGDFGVQL DLGFLTANKA YTFFKPKFIF YATYLSEKIG
     YWRYIAIYRH LEQNPDSKIF PIFNFFENWC QDENRHGDFF DALMKAQPSS VRGLQARLWC
     RFFLLAVFAT MYVRDVARKE FYEALGLDAR EYDKYVIAKT NETSARVFPV VLNVDHPKFY
     ERLERIVGNN NALSQADASG ASAPVRLLRK LPFWGANALE MAKLFFAAPI RSENYQPAIR
//