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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciSSP316278:G1GJL-1429-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:SynRCC307_1473
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001115 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201911 – 330Methionyl-tRNA formyltransferaseAdd BLAST330

Interactioni

Protein-protein interaction databases

STRINGi316278.SynRCC307_1473.

Structurei

3D structure databases

ProteinModelPortaliA5GU17.
SMRiA5GU17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni112 – 115Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiLRIVFMG.
OrthoDBiPOG091H01YM.

Family and domain databases

HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR036477. Formyl_transf_N_sf.
IPR011034. Formyl_transferase-like_C_sf.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GU17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLFWGTPA YAVPTLEALH GAGHQIVGVV TQPDRRRGRG SSLMPSPVKA
60 70 80 90 100
RALDLLGDVP VLTPQRIRRE PETQEQLAAL QADLSVVVAF GQLLPPEVLQ
110 120 130 140 150
QPPLGCWNGH GSLLPRWRGA GPIQWCLMEG DAQTGVGIMA MEPGLDTGPV
160 170 180 190 200
LLERALDVQL LENAAGLAER LSHLTAELFV EALPRIEAAG PGPEAERLSR
210 220 230 240 250
LAVTPQSDEG VSLARLLSKD DYRIDWSERA LAIHRKVMGL FPGAHCSWRG
260 270 280 290 300
KRLKLLATEP LVARLADQLS PQAAALSQRQ WPSAEPGSIL EAVRGVGLVL
310 320 330
ATSGCPILLR QAQLEGKAAS SGDSLIQQLS
Length:330
Mass (Da):35,405
Last modified:June 12, 2007 - v1
Checksum:i46D3A5FF548E7006
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA. Translation: CAK28376.1.
RefSeqiWP_011935890.1. NC_009482.1.

Genome annotation databases

EnsemblBacteriaiCAK28376; CAK28376; SynRCC307_1473.
KEGGisyr:SynRCC307_1473.

Similar proteinsi

Entry informationi

Entry nameiFMT_SYNR3
AccessioniPrimary (citable) accession number: A5GU17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome