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A5GTX8 (KATG_SYNR3) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Catalase-peroxidase
Short name=CP
EC=1.11.1.21
Alternative name(s):
Peroxidase/catalase
Gene names
Name:katG
Ordered Locus Names:SynRCC307_1434
OrganismSynechococcus sp. (strain RCC307) [Complete proteome] [HAMAP]
Taxonomic identifier316278 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length732 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961

Catalytic activity

Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961

2 H2O2 = O2 + 2 H2O. HAMAP MF_01961

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.

Subunit structure

Homodimer or homotetramer By similarity. HAMAP MF_01961

Post-translational modification

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
   Biological processHydrogen peroxide
   DomainSignal
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncatalase activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 732710Catalase-peroxidase HAMAP MF_01961
PRO_0000354944

Sites

Active site981Proton acceptor By similarity
Metal binding2611Iron (heme axial ligand) By similarity
Site941Transition state stabilizer By similarity

Amino acid modifications

Cross-link97 ↔ 220Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-246) By similarity
Cross-link220 ↔ 246Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97) By similarity

Sequences

Sequence LengthMass (Da)Tools
A5GTX8 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 9F8A4D9287C25390

FASTA73280,124
        10         20         30         40         50         60 
MSMAEMRCPF SGHGAATTPA SATTNQHWWP EQINLGLLHQ HNPAANPLGS NFDYRQAFNS 

        70         80         90        100        110        120 
LDLNAVKADL MALMTDSQSW WPADWGHYGG LFIRMAWHSA GTYRLADGRG GAGHGNQRFA 

       130        140        150        160        170        180 
PLNSWPDNTN LDKARRLLWP IKAKYGSNLS WADLIILAGN CALESMGLPT AGFAGGREDI 

       190        200        210        220        230        240 
WEPEDDIYWG SETSWLSDER HDNDGAIESP LAATEMGLIY VNPEGPHGEP DPVASGREVR 

       250        260        270        280        290        300 
DTFARMGMNN EETVALVAGG HTFGKAHGAA PSAHLGADPE GAALEQLGLG WQNTYASGCG 

       310        320        330        340        350        360 
ADTITSGIEG AWKPNPTRWD QGYFEMLFGY EWELHQSPAG AWQWHPKDVK AEHMIPDAHV 

       370        380        390        400        410        420 
PGRSAPPMMT TADLSLRFDP VYEPIARRFL GDPQAFGNAF AQAWFKLTHR DLGPRSCYLG 

       430        440        450        460        470        480 
ADVPEAVMSW QDPLPTTSHP TIDAPAVDAL KQELLNTGLS HGELISTAWA SAASFRQSDR 

       490        500        510        520        530        540 
RGGANGARLR LQPQCNWELN NPEQLKRVLS VLEAVQMRFN QQHQGGMQVS LADLIVLSGS 

       550        560        570        580        590        600 
AAVEQAMAAT GQRCRVRFTP GRVDASAEQT DNASFNALKP IADGFRNYLR SDLPLKAEQL 

       610        620        630        640        650        660 
LVDRAQQLHL SAPEMTALIG GFRVLGLNWD GSDIGVFTSR PGQFSNDFFV NLLDMSTQWS 

       670        680        690        700        710        720 
PVEGHSNLYQ GIDTETKQPR WRASRVDLVF GSHAQLRAIA EVYGQAGGSA RLAADFSAAW 

       730 
SKVMELDRFD LL

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCC307.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT978603 Genomic DNA. Translation: CAK28337.1.
RefSeqYP_001227690.1. NC_009482.1.

3D structure databases

ProteinModelPortalA5GTX8.
SMRA5GTX8. Positions 21-731.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5GTX8.

Protein family/group databases

PeroxiBase6243. SspCP01_RCC307.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5158398.
GenomeReviewsGene locus SynRCC307_1434 in contig CT978603_GR.
KEGGsyr:SynRCC307_1434.
PATRIC23823767. VBISynSp108374_1435.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0376.
HOGENOMHBG285610.
OMAKRHAPSM.
PhylomeDBA5GTX8.
ProtClustDBPRK15061.

Family and domain databases

HAMAPMF_01961. Catal-peroxid.
[Tree]
InterProIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
KOK03782.
PfamPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMSSF48113. Peroxidase_super. 2 hits.
TIGRFAMsTIGR00198. Cat_per_HPI. 1 hit.
PROSITEPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKATG_SYNR3
AccessionPrimary (citable) accession number: A5GTX8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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