A5GTU8 (A5GTU8_SYNR3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 4 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 4 HAMAP MF_00444

Gene names

Name:	clpP EMBL CAK28307.1
Synonyms:	clpP4 HAMAP MF_00444
Ordered Locus Names:	SynRCC307_1404

Organism

Synechococcus sp. (strain RCC307) [Complete proteome] [HAMAP]

Taxonomic identifier

316278 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. RuleBase RU003567 HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	96	1	By similarity HAMAP MF_00444
	Active site	121	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	A5GTU8 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: F3CB28E1FB3AEDDE	FASTA	196	21,693
	10 20 30 40 50 60 MIPIVIEESG RGERAFDIYS RLLRERIIFM GEPVTAESAN RIVAQLLFLE AEDPDKDIFL 70 80 90 100 110 120 YINSPGGSVY DGLGIFDTMQ HVKPDVQTVC VGLAASMGAF LLAAGAPGKR SSLQHSRIMI 130 140 150 160 170 180 HQPLGGAQGQ ASDIRIQADE ILFLKKRLNE ELAQRTGQPL DRIQKDTDRD FFMSPAEAAE 190 YGLIDKVIDQ RPIHAI

References

[1]	Genoscope Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT978603 Genomic DNA. Translation: CAK28307.1.
RefSeq	YP_001227660.1. NC_009482.1.
3D structure databases
ProteinModelPortal	A5GTU8.
SMR	A5GTU8. Positions 1-191.
ModBase	Search...
Protein-protein interaction databases
STRING	A5GTU8.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5158303.
GenomeReviews	Gene locus SynRCC307_1404 in contig CT978603_GR.
KEGG	syr:SynRCC307_1404.
PATRIC	23823707. VBISynSp108374_1405.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HBG558421.
OMA	QHSRIMI.
ProtClustDB	PRK12551.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. ClpP. 1 hit.
PROSITE	PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5GTU8_SYNR3

Accession

Primary (citable) accession number: A5GTU8

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)