Skip Header

Contribute Send feedback
Read comments (?) or add your own

A5GTE6 (A5GTE6_SYNR3) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL CAK28155.1
Ordered Locus Names:SynRCC307_1252
OrganismSynechococcus sp. (strain RCC307) [Complete proteome] [HAMAP]
Taxonomic identifier316278 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000109-3
Region129 – 1313Substrate binding By similarity PIRSR PIRSR000109-2
Region186 – 1872Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1831Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1901Proton donor By similarity PIRSR PIRSR000109-1
Binding site1031NADP By similarity PIRSR PIRSR000109-3
Binding site1031Substrate By similarity PIRSR PIRSR000109-2
Binding site1911Substrate By similarity PIRSR PIRSR000109-2
Binding site2621Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2891Substrate By similarity PIRSR PIRSR000109-2
Binding site4491Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4551Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A5GTE6 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: B7113BD965A89FD4

FASTA47251,071
        10         20         30         40         50         60 
MGKGHFGLIG LGVMGENLVL NAERNGFSSV VYNRTRQKTD EFMAGRGAGK QIQPAYSLQE 

        70         80         90        100        110        120 
FVDKLERPRR ILMMVKAGGA VDAVIDQISP YLEAGDLLID GGNSEYKDTE RRVAKLESQS 

       130        140        150        160        170        180 
FGFIGMGVSG GAKGALEGPS MMPGGTKASY DAIESLVTKM AAQVEDGPCV TYIGPGGSGH 

       190        200        210        220        230        240 
FVKTVHNGIE YGIEQILAEA YDLMKRVKGM NGEQIADVFK AWNATEELNS YLVEITEVCL 

       250        260        270        280        290        300 
RTKDPDDGTD LVEKIMDQAG QKGTGLWTVV TALEMGASVP TIYAALNGRV MSSMKPQRQK 

       310        320        330        340        350        360 
AESILKGPAV ADADLGSPSD AMGPIMDAVV LSCIASYAQG MELLRIASAD NNYNLHMPAI 

       370        380        390        400        410        420 
AQIWKGGCII RAKLLKRIQD AFNADPQLPN LMIDPWFADQ VNRRLPGLAK VVAASAANGI 

       430        440        450        460        470 
PVPTFSSTLD YINSYRTGRL PQNLVQAMRD CFGSHTYQRV DRDGTFHTEW LQ

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT978603 Genomic DNA. Translation: CAK28155.1.
RefSeqYP_001227508.1. NC_009482.1.

3D structure databases

ProteinModelPortalA5GTE6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5GTE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5158746.
GenomeReviewsGene locus SynRCC307_1252 in contig CT978603_GR.
KEGGsyr:SynRCC307_1252.
PATRIC23823399. VBISynSp108374_1253.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBA5GTE6.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5GTE6_SYNR3
AccessionPrimary (citable) accession number: A5GTE6
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info