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A5GT82 (SYL_SYNR3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:SynRCC307_1188
OrganismSynechococcus sp. (strain RCC307) [Complete proteome] [HAMAP]
Taxonomic identifier316278 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length864 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 864864Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334831

Regions

Motif47 – 5711"HIGH" region HAMAP-Rule MF_00049
Motif622 – 6265"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6251ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5GT82 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 2BEF084AA3D038F1

FASTA86496,134
        10         20         30         40         50         60 
MASSESRYSP TSLEPKWQQR WQEMGLDQTP EPSAERAENF YALSMFPYPS GNLHMGHVRN 

        70         80         90        100        110        120 
YVITDVIARL MRLKGKRVLH PMGWDAFGLP AENAAIERGV DPADWTDRNI AQMREQLQRL 

       130        140        150        160        170        180 
GLSIDWSREV ATCHSDYYRW TQWLFLQFLN ADLAYRKEAT VNWDPIDQTV LANEQVDADG 

       190        200        210        220        230        240 
RSWRSGALAE KRKLRQWFLK ITAVADELLD DLEQLKGWPE RVRTMQANWI GRSSGATLRF 

       250        260        270        280        290        300 
AIEADGKQAI EVFTTRPDTV FGVSYVVLAP EHDLVDQLTS ADQRQAVEAF RQSLQSISEQ 

       310        320        330        340        350        360 
DRVADDRPKR GVATGGTVQH PFTGQAVPVW IADYVLPDYG TGAVMGVPAH DSRDFAFAKQ 

       370        380        390        400        410        420 
YDLPITTVVV EPGQAPDSGE PSEAFTGLGE LVGSADFDGL QGEEAKTAII QAAEQRGVGA 

       430        440        450        460        470        480 
AKITFRLRDW LISRQRYWGC PIPVIHCDDC GVVPVPESDL PVELPRDVDL SGSGGSPLER 

       490        500        510        520        530        540 
ATEWKQVRCP KCGKPATRET DTMDTFMCSS WYYLRYTDAN NDSAAFTNAS IDAWMPVDQY 

       550        560        570        580        590        600 
VGGVEHAILH LLYSRFFTKV LQQRNLVSCS EPFQKLLTQG MVQGVTYRNP KTRKYIAPSA 

       610        620        630        640        650        660 
VSDPNQPTDP DDGEALEVFF EKMSKSKYNG VDPGAVVDRY GADTARMFIL FKAPPEKDLE 

       670        680        690        700        710        720 
WDDADVEGQF RFLQRIWRLC DGAKASGLQL QSPLPLPAEL TPAETDLRRA VHTAIEAVSD 

       730        740        750        760        770        780 
DLQGDELQFN TAVSELMKLS NAMAGQLEAV STAVAQEAVR SLLLLLAPFA PHLADELWEQ 

       790        800        810        820        830        840 
LQGSGSIHQQ RWPEVDASAL VRDTITVVLQ VKGKVRGNLE VPAAISKDEL EQVALASDVA 

       850        860 
QKWLEGNAPK RVIVVPGKLV NLVP 

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCC307.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT978603 Genomic DNA. Translation: CAK28091.1.
RefSeqYP_001227444.1. NC_009482.1.

3D structure databases

ProteinModelPortalA5GT82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316278.SynRCC307_1188.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK28091; CAK28091; SynRCC307_1188.
GeneID5156746.
KEGGsyr:SynRCC307_1188.
PATRIC23823273. VBISynSp108374_1191.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_SYNR3
AccessionPrimary (citable) accession number: A5GT82
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries