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A5GT82

- SYL_SYNR3

UniProt

A5GT82 - SYL_SYNR3

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SynRCC307_1188
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001115: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligasePRO_0000334831Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316278.SynRCC307_1188.

Structurei

3D structure databases

ProteinModelPortaliA5GT82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionAdd
BLAST
Motifi622 – 6265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GT82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSESRYSP TSLEPKWQQR WQEMGLDQTP EPSAERAENF YALSMFPYPS
60 70 80 90 100
GNLHMGHVRN YVITDVIARL MRLKGKRVLH PMGWDAFGLP AENAAIERGV
110 120 130 140 150
DPADWTDRNI AQMREQLQRL GLSIDWSREV ATCHSDYYRW TQWLFLQFLN
160 170 180 190 200
ADLAYRKEAT VNWDPIDQTV LANEQVDADG RSWRSGALAE KRKLRQWFLK
210 220 230 240 250
ITAVADELLD DLEQLKGWPE RVRTMQANWI GRSSGATLRF AIEADGKQAI
260 270 280 290 300
EVFTTRPDTV FGVSYVVLAP EHDLVDQLTS ADQRQAVEAF RQSLQSISEQ
310 320 330 340 350
DRVADDRPKR GVATGGTVQH PFTGQAVPVW IADYVLPDYG TGAVMGVPAH
360 370 380 390 400
DSRDFAFAKQ YDLPITTVVV EPGQAPDSGE PSEAFTGLGE LVGSADFDGL
410 420 430 440 450
QGEEAKTAII QAAEQRGVGA AKITFRLRDW LISRQRYWGC PIPVIHCDDC
460 470 480 490 500
GVVPVPESDL PVELPRDVDL SGSGGSPLER ATEWKQVRCP KCGKPATRET
510 520 530 540 550
DTMDTFMCSS WYYLRYTDAN NDSAAFTNAS IDAWMPVDQY VGGVEHAILH
560 570 580 590 600
LLYSRFFTKV LQQRNLVSCS EPFQKLLTQG MVQGVTYRNP KTRKYIAPSA
610 620 630 640 650
VSDPNQPTDP DDGEALEVFF EKMSKSKYNG VDPGAVVDRY GADTARMFIL
660 670 680 690 700
FKAPPEKDLE WDDADVEGQF RFLQRIWRLC DGAKASGLQL QSPLPLPAEL
710 720 730 740 750
TPAETDLRRA VHTAIEAVSD DLQGDELQFN TAVSELMKLS NAMAGQLEAV
760 770 780 790 800
STAVAQEAVR SLLLLLAPFA PHLADELWEQ LQGSGSIHQQ RWPEVDASAL
810 820 830 840 850
VRDTITVVLQ VKGKVRGNLE VPAAISKDEL EQVALASDVA QKWLEGNAPK
860
RVIVVPGKLV NLVP
Length:864
Mass (Da):96,134
Last modified:June 12, 2007 - v1
Checksum:i2BEF084AA3D038F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA. Translation: CAK28091.1.
RefSeqiWP_011935605.1. NC_009482.1.
YP_001227444.1. NC_009482.1.

Genome annotation databases

EnsemblBacteriaiCAK28091; CAK28091; SynRCC307_1188.
GeneIDi5156746.
KEGGisyr:SynRCC307_1188.
PATRICi23823273. VBISynSp108374_1191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA. Translation: CAK28091.1 .
RefSeqi WP_011935605.1. NC_009482.1.
YP_001227444.1. NC_009482.1.

3D structure databases

ProteinModelPortali A5GT82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316278.SynRCC307_1188.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK28091 ; CAK28091 ; SynRCC307_1188 .
GeneIDi 5156746.
KEGGi syr:SynRCC307_1188.
PATRICi 23823273. VBISynSp108374_1191.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCC307.

Entry informationi

Entry nameiSYL_SYNR3
AccessioniPrimary (citable) accession number: A5GT82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3