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A5GT82

- SYL_SYNR3

UniProt

A5GT82 - SYL_SYNR3

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Protein
Leucine--tRNA ligase
Gene
leuS, SynRCC307_1188
Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SynRCC307_1188
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001115: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligaseUniRule annotation
PRO_0000334831Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316278.SynRCC307_1188.

Structurei

3D structure databases

ProteinModelPortaliA5GT82.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionUniRule annotation
Add
BLAST
Motifi622 – 6265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GT82-1 [UniParc]FASTAAdd to Basket

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MASSESRYSP TSLEPKWQQR WQEMGLDQTP EPSAERAENF YALSMFPYPS    50
GNLHMGHVRN YVITDVIARL MRLKGKRVLH PMGWDAFGLP AENAAIERGV 100
DPADWTDRNI AQMREQLQRL GLSIDWSREV ATCHSDYYRW TQWLFLQFLN 150
ADLAYRKEAT VNWDPIDQTV LANEQVDADG RSWRSGALAE KRKLRQWFLK 200
ITAVADELLD DLEQLKGWPE RVRTMQANWI GRSSGATLRF AIEADGKQAI 250
EVFTTRPDTV FGVSYVVLAP EHDLVDQLTS ADQRQAVEAF RQSLQSISEQ 300
DRVADDRPKR GVATGGTVQH PFTGQAVPVW IADYVLPDYG TGAVMGVPAH 350
DSRDFAFAKQ YDLPITTVVV EPGQAPDSGE PSEAFTGLGE LVGSADFDGL 400
QGEEAKTAII QAAEQRGVGA AKITFRLRDW LISRQRYWGC PIPVIHCDDC 450
GVVPVPESDL PVELPRDVDL SGSGGSPLER ATEWKQVRCP KCGKPATRET 500
DTMDTFMCSS WYYLRYTDAN NDSAAFTNAS IDAWMPVDQY VGGVEHAILH 550
LLYSRFFTKV LQQRNLVSCS EPFQKLLTQG MVQGVTYRNP KTRKYIAPSA 600
VSDPNQPTDP DDGEALEVFF EKMSKSKYNG VDPGAVVDRY GADTARMFIL 650
FKAPPEKDLE WDDADVEGQF RFLQRIWRLC DGAKASGLQL QSPLPLPAEL 700
TPAETDLRRA VHTAIEAVSD DLQGDELQFN TAVSELMKLS NAMAGQLEAV 750
STAVAQEAVR SLLLLLAPFA PHLADELWEQ LQGSGSIHQQ RWPEVDASAL 800
VRDTITVVLQ VKGKVRGNLE VPAAISKDEL EQVALASDVA QKWLEGNAPK 850
RVIVVPGKLV NLVP 864
Length:864
Mass (Da):96,134
Last modified:June 12, 2007 - v1
Checksum:i2BEF084AA3D038F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK28091.1.
RefSeqiWP_011935605.1. NC_009482.1.
YP_001227444.1. NC_009482.1.

Genome annotation databases

EnsemblBacteriaiCAK28091; CAK28091; SynRCC307_1188.
GeneIDi5156746.
KEGGisyr:SynRCC307_1188.
PATRICi23823273. VBISynSp108374_1191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK28091.1 .
RefSeqi WP_011935605.1. NC_009482.1.
YP_001227444.1. NC_009482.1.

3D structure databases

ProteinModelPortali A5GT82.
ModBasei Search...

Protein-protein interaction databases

STRINGi 316278.SynRCC307_1188.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK28091 ; CAK28091 ; SynRCC307_1188 .
GeneIDi 5156746.
KEGGi syr:SynRCC307_1188.
PATRICi 23823273. VBISynSp108374_1191.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCC307.

Entry informationi

Entry nameiSYL_SYNR3
AccessioniPrimary (citable) accession number: A5GT82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi