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A5GS98 (HEMH_SYNR3) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:SynRCC307_0854
OrganismSynechococcus sp. (strain RCC307) [Complete proteome] [HAMAP]
Taxonomic identifier316278 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Ferrochelatase HAMAP MF_00323
PRO_1000019379

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A5GS98 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: E0F476819DD5F39E

FASTA38743,378
        10         20         30         40         50         60 
MSRVGIVLLN LGGPERIQDV GPFLYNLFAD PEIIRLPIPA LQKPLAWLIS TLRSNKSQEA 

        70         80         90        100        110        120 
YRSIGGGSPL RRITDQQARE LQSLLRQRNV DATTYVAMRY WHPFTESAVA DMKADGIEQV 

       130        140        150        160        170        180 
VVLPLYPHFS ISTSGSSFRE LQRLRQGDER FAQLPLRAIR SWHDHPGYLK AMAQLMEREI 

       190        200        210        220        230        240 
DACVDPSTAH VFFSAHGVPK SYVEEAGDPY QKEIESCAEL IMKTLGRDNP WTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLQPYTE EALEELGEKG VKELVVVPIS FVSEHIETLE EIDIEYREIA TEAGVSNFRR 

       310        320        330        340        350        360 
VPALDIDPTF IASLADLVET SLAGPEVDLD EAAALPARTK LYPQEKWSWG WNNSSEVWNG 

       370        380 
RLAMLGFSAF LVELISGHGP LHALGLL

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCC307.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT978603 Genomic DNA. Translation: CAK27757.1.
RefSeqYP_001227110.1. NC_009482.1.

3D structure databases

ProteinModelPortalA5GS98.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5GS98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5157571.
GenomeReviewsGene locus SynRCC307_0854 in contig CT978603_GR.
KEGGsyr:SynRCC307_0854.
PATRIC23822582. VBISynSp108374_0848.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBA5GS98.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR023329. Chlorophyll_a/b-bd_dom.
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
Gene3DG3DSA:1.10.3460.10. G3DSA:1.10.3460.10. 1 hit.
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_SYNR3
AccessionPrimary (citable) accession number: A5GS98
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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