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A5GRD7

- PNP_SYNR3

UniProt

A5GRD7 - PNP_SYNR3

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi495 – 4951MagnesiumUniRule annotation
    Metal bindingi501 – 5011MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:SynRCC307_0543
    OrganismiSynechococcus sp. (strain RCC307)
    Taxonomic identifieri316278 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001115: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 719719Polyribonucleotide nucleotidyltransferasePRO_0000329902Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316278.SynRCC307_0543.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GRD7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini562 – 62160KHUniRule annotationAdd
    BLAST
    Domaini631 – 69969S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5GRD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQGETRSISF DGREIRLTTR RYAPQAGGSV LIECGDTAVL VTATRANGRE    50
    GIDFLPLTCD YEERLYAAGR IPGSFMRRES RPPERATLAC RLIDRPIRPL 100
    FPSWMRDDLQ IVATVMSVDE RVPPDVLAVT GASLATLLAK IPFYGPMAAV 150
    RVGLLGDDFI LNPSYREIER SELDLVVAGT AEGVVMVEAG AQQLPEEDMI 200
    EAIDFGYEAV LELIRHQKET IAELGIEQVV PEKPAEDTTV PDYLAKQCTK 250
    DIGAVLSQFT LTKAERDSQL DSIKAKAAEA IAALKETDAV RAAVSSNGKL 300
    LGNSFKALTK SMMRAQIVKD GKRVDGRSLD QVRPISAAAG VLPKRVHGSG 350
    LFQRGLTQVL STATLGTPSD AQEMDDLNPS NEKHYLHHYN FPPYSVGETR 400
    PMRSPGRREI GHGALAERAL LPVLPPKESF PYVLRVVSEV LSSNGSTSMG 450
    SVCGSTLALM DAGVPIAAPV AGAAMGLIRE GSEVRVLTDI QGIEDFLGDM 500
    DFKVAGTEKG ITALQMDMKI TGLAMKTIGE AVTQARPARL HILEKMLEAL 550
    DKPRDTMSPH APRRLSFRID PELIGTVIGP GGRTIKGITE RTNTKIDIED 600
    TGIVTVASHD GAAAEEAQKI IEGLTRRVSE GEYFDGKVTR VIPIGAFVEI 650
    LPGKEGMIHI SQLSDQRVEK VEDVVNVGDE VRVRVREIDN RGRINLTLRG 700
    VPQDGSDPQP TVILPIGES 719
    Length:719
    Mass (Da):77,871
    Last modified:June 12, 2007 - v1
    Checksum:iAB89C0A1B73E63FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT978603 Genomic DNA. Translation: CAK27446.1.
    RefSeqiWP_011934961.1. NC_009482.1.
    YP_001226799.1. NC_009482.1.

    Genome annotation databases

    EnsemblBacteriaiCAK27446; CAK27446; SynRCC307_0543.
    GeneIDi5158380.
    KEGGisyr:SynRCC307_0543.
    PATRICi23821946. VBISynSp108374_0536.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT978603 Genomic DNA. Translation: CAK27446.1 .
    RefSeqi WP_011934961.1. NC_009482.1.
    YP_001226799.1. NC_009482.1.

    3D structure databases

    ProteinModelPortali A5GRD7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316278.SynRCC307_0543.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK27446 ; CAK27446 ; SynRCC307_0543 .
    GeneIDi 5158380.
    KEGGi syr:SynRCC307_0543.
    PATRICi 23821946. VBISynSp108374_0536.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RCC307.

    Entry informationi

    Entry nameiPNP_SYNR3
    AccessioniPrimary (citable) accession number: A5GRD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3