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A5GR03 (PYRC_SYNR3) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase
Short name=DHOase
EC=3.5.2.3
Gene names
Name:pyrC
Ordered Locus Names:SynRCC307_0409
OrganismSynechococcus sp. (strain RCC307) [Complete proteome] [HAMAP]
Taxonomic identifier316278 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00219

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00219

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219

Subunit structure

Homodimer By similarity. HAMAP MF_00219

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyrimidine base biosynthetic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiondihydroorotase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Dihydroorotase HAMAP MF_00219
PRO_0000325579

Sites

Metal binding171Zinc 1 By similarity
Metal binding191Zinc 1 By similarity
Metal binding1031Zinc 1; via carbamate group By similarity
Metal binding1031Zinc 2; via carbamate group By similarity
Metal binding1401Zinc 2 By similarity
Metal binding1781Zinc 2 By similarity
Metal binding2511Zinc 1 By similarity

Amino acid modifications

Modified residue1031N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A5GR03 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: A71F7C06A5CCC1BA

FASTA34638,412
        10         20         30         40         50         60 
MTPAPDQLVL RRPDDWHVHL RDDVMLEQVL PATARQFARA IVMPNLRPPV TTVDAAIAYR 

        70         80         90        100        110        120 
QRIEAALPDG MAFTPLMTAY LTDDISPDEL ERGHREGVFT AAKLYPANAT TNSAAGVSDL 

       130        140        150        160        170        180 
ACITAVLERM QAIDMPLLIH GEVTDPDIDI FDREAVFIER HLIPLRRQFP QLRVVFEHIT 

       190        200        210        220        230        240 
TEQAAQFVVD GDPLMAATIT PHHLHINRNA MFQGGLRSDF YCLPVAKRER HRLALRQAAT 

       250        260        270        280        290        300 
SGDPSFFLGT DSAPHPRAGK ESSCGCAGIY NAPYALESYL AVFEAEGALQ HFEAFASENG 

       310        320        330        340 
PRFYKLPLNE DTITLKRTAQ LVPAQLEGQG LVPFHASEVL DWRLAD

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCC307.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT978603 Genomic DNA. Translation: CAK27312.1.
RefSeqYP_001226665.1. NC_009482.1.

3D structure databases

ProteinModelPortalA5GR03.
SMRA5GR03. Positions 8-344.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5GR03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5157973.
GenomeReviewsGene locus SynRCC307_0409 in contig CT978603_GR.
KEGGsyr:SynRCC307_0409.
PATRIC23821662. VBISynSp108374_0399.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHBG628648.
OMACLPVAKR.
ProtClustDBPRK05451.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. False negative.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRC_SYNR3
AccessionPrimary (citable) accession number: A5GR03
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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