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A5GQU9

- DEF_SYNR3

UniProt

A5GQU9 - DEF_SYNR3

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Protein
Peptide deformylase
Gene
def, SynRCC307_0355
Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi121 – 1211Iron By similarity
Metal bindingi163 – 1631Iron By similarity
Active sitei164 – 1641 By similarity
Metal bindingi167 – 1671Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:SynRCC307_0355
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001115: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Peptide deformylaseUniRule annotation
PRO_1000023136Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316278.SynRCC307_0355.

Structurei

3D structure databases

ProteinModelPortaliA5GQU9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiQQANNST.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GQU9-1 [UniParc]FASTAAdd to Basket

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MSLNFAAMAR QSERQASTVM VPKGEEQPES PKIHTLGSNE LRKPAKRISK    50
VNEQVRELAR EMLRSMYAAH GIGLAAPQVG VHQQLLVIDL DPEEAANPPL 100
VLINPEIVAT SGALDTYEEG CLSIPGVYLN VVRPSQVDVK YRDELGRPQR 150
RKADGLMARC ILHEMDHLNG VLFVDRVSDE LSLSGELQRL GFDRNDVKPV 200
A 201
Length:201
Mass (Da):22,242
Last modified:June 12, 2007 - v1
Checksum:i62594446FEBFC7CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK27258.1.
RefSeqiWP_011934773.1. NC_009482.1.
YP_001226611.1. NC_009482.1.

Genome annotation databases

EnsemblBacteriaiCAK27258; CAK27258; SynRCC307_0355.
GeneIDi5156497.
KEGGisyr:SynRCC307_0355.
PATRICi23821540. VBISynSp108374_0343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK27258.1 .
RefSeqi WP_011934773.1. NC_009482.1.
YP_001226611.1. NC_009482.1.

3D structure databases

ProteinModelPortali A5GQU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316278.SynRCC307_0355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK27258 ; CAK27258 ; SynRCC307_0355 .
GeneIDi 5156497.
KEGGi syr:SynRCC307_0355.
PATRICi 23821540. VBISynSp108374_0343.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi QQANNST.
OrthoDBi EOG664CMF.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCC307.

Entry informationi

Entry nameiDEF_SYNR3
AccessioniPrimary (citable) accession number: A5GQU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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