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A5GQQ0

- UPPP_SYNR3

UniProt

A5GQQ0 - UPPP_SYNR3

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, SynRCC307_0306
Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:SynRCC307_0306
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001115: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei49 – 6921Helical; Reviewed prediction
Add
BLAST
Transmembranei98 – 11821Helical; Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Transmembranei261 – 28121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Undecaprenyl-diphosphataseUniRule annotation
PRO_0000303037Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316278.SynRCC307_0306.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GQQ0-1 [UniParc]FASTAAdd to Basket

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MDAAAELTLL EACWRTVVLG IVQGLTEFLP ISSTAHLKVV PVLAGWGDPG    50
VAVTAVIQLG SIAAVIGYFR SDLLQVCRGL ARALREGDWG SPDARLGIAI 100
AVGTLPVVVA GLLIKLFWPG YETSPLRSVA SIGIVSIVMA LLLALAERLG 150
QRRKQLPSVQ GLDGVVVGLA QALAIIPGVS RSGSTLTASL LFGWQRSDAA 200
RFSFLLGIPA ITLAGLVELK GAFAEGSVYG PLPMLLGILS AAVVSWLAIA 250
WLLKFLQTNS TWPFVIYRLV FGVVLLALVL ANPTLG 286
Length:286
Mass (Da):29,970
Last modified:June 12, 2007 - v1
Checksum:iC638DC3B49329606
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK27209.1.
RefSeqiWP_011934724.1. NC_009482.1.
YP_001226562.1. NC_009482.1.

Genome annotation databases

EnsemblBacteriaiCAK27209; CAK27209; SynRCC307_0306.
GeneIDi5158866.
KEGGisyr:SynRCC307_0306.
PATRICi23821440. VBISynSp108374_0294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT978603 Genomic DNA. Translation: CAK27209.1 .
RefSeqi WP_011934724.1. NC_009482.1.
YP_001226562.1. NC_009482.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316278.SynRCC307_0306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK27209 ; CAK27209 ; SynRCC307_0306 .
GeneIDi 5158866.
KEGGi syr:SynRCC307_0306.
PATRICi 23821440. VBISynSp108374_0294.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCC307.

Entry informationi

Entry nameiUPPP_SYNR3
AccessioniPrimary (citable) accession number: A5GQQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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