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A5GPX7

- PDXA_SYNR3

UniProt

A5GPX7 - PDXA_SYNR3

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei125 – 1251SubstrateUniRule annotation
    Metal bindingi160 – 1601Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi203 – 2031Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi269 – 2691Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei277 – 2771SubstrateUniRule annotation
    Binding sitei286 – 2861SubstrateUniRule annotation
    Binding sitei295 – 2951SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:SynRCC307_0033
    OrganismiSynechococcus sp. (strain RCC307)
    Taxonomic identifieri316278 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001115: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3283284-hydroxythreonine-4-phosphate dehydrogenasePRO_1000051523Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi316278.SynRCC307_0033.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GPX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221591.
    KOiK00097.
    OMAiISIKLAM.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5GPX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRLAIALGD PAGIGAEVVL KALAHRPSLN PLLVGCRQWL QASYEQLLPC    50
    CHEPLADPSQ LEILDEPLTE AITPGSISAA AGAASFGWLT RATEAVLDGR 100
    AQALVTAPIA KTAWHQAGHH YPGQTERLAE LCGCDDAAML FTARSPQSGW 150
    RFNTLLATTH IPLSSVPAAL TPERLERRLG QLEDFCRRFR QRPRLRVAGL 200
    NPHAGEAGQL GTEEQRWITA CLQAYQQRHN NLQLEGPVPP DTCWLGAAQA 250
    WNDSQHVEEG CDGYLALYHD QGLIPVKVLA FDQAVNTTLG LPFLRTSPDH 300
    GTGFDRAGQG SARGASMLAA IDTAVELG 328
    Length:328
    Mass (Da):35,324
    Last modified:June 12, 2007 - v1
    Checksum:iDB8197D66D80824B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT978603 Genomic DNA. Translation: CAK26936.1.
    RefSeqiWP_011934451.1. NC_009482.1.
    YP_001226289.1. NC_009482.1.

    Genome annotation databases

    EnsemblBacteriaiCAK26936; CAK26936; SynRCC307_0033.
    GeneIDi5156516.
    KEGGisyr:SynRCC307_0033.
    PATRICi23820910. VBISynSp108374_0033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT978603 Genomic DNA. Translation: CAK26936.1 .
    RefSeqi WP_011934451.1. NC_009482.1.
    YP_001226289.1. NC_009482.1.

    3D structure databases

    ProteinModelPortali A5GPX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316278.SynRCC307_0033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK26936 ; CAK26936 ; SynRCC307_0033 .
    GeneIDi 5156516.
    KEGGi syr:SynRCC307_0033.
    PATRICi 23820910. VBISynSp108374_0033.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221591.
    KOi K00097.
    OMAi ISIKLAM.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RCC307.

    Entry informationi

    Entry nameiPDXA_SYNR3
    AccessioniPrimary (citable) accession number: A5GPX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3