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A5GPT0

- ASSY_SYNPW

UniProt

A5GPT0 - ASSY_SYNPW

Protein

Argininosuccinate synthase

Gene

argG

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei89 – 891CitrullineUniRule annotation
    Binding sitei119 – 1191ATP; via amide nitrogenUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei129 – 1291CitrullineUniRule annotation
    Binding sitei177 – 1771CitrullineUniRule annotation
    Binding sitei186 – 1861CitrullineUniRule annotation
    Binding sitei262 – 2621CitrullineUniRule annotation
    Binding sitei274 – 2741CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:SynWH7803_2519
    OrganismiSynechococcus sp. (strain WH7803)
    Taxonomic identifieri32051 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001566: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Argininosuccinate synthasePRO_1000000444Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi32051.SynWH7803_2519.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GPT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiYAFPAIK.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5GPT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRAKKVVLA YSGGVDTSVC IPYLKQEWGV EEVITFAADL GQGDELEPIR    50
    RKALEAGASQ SLVGDLIQPF IEEFAFPAIR ANALYEGRYP LSTALARPLI 100
    ARRLVEVARE VGADAVAHGC TGKGNDQVRF DVAIAALAPD LKVLTPAREW 150
    GMSREETIAY GERCGLPAPV SKKSPYSIDL NLLGRSVEAG PLEDPMQAPP 200
    EEVFAMTVSI DAAPSEAEEI EIAFEAGNPV SINGQRLDPV ALIREANRLA 250
    GSHGIGRLDM IENRVVGIKS REIYETPGLL LLIQAHQELE SLTLAADVLR 300
    TKRQLEMQWA DLVYQGLWFG PLKEALDGFM DRTQSEVNGV VRLRLHKGNA 350
    IVTGRGSSDS SLYVPEMASY GSEDQFDHRA AEGFIYVWGL PIRLWSAARR 400
    R 401
    Length:401
    Mass (Da):43,851
    Last modified:June 12, 2007 - v1
    Checksum:iDF06E44811DD83F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK24945.1.
    RefSeqiWP_011934404.1. NC_009481.1.
    YP_001226242.1. NC_009481.1.

    Genome annotation databases

    EnsemblBacteriaiCAK24945; CAK24945; SynWH7803_2519.
    GeneIDi5147543.
    KEGGisyx:SynWH7803_2519.
    PATRICi23831336. VBISynSp43824_2604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK24945.1 .
    RefSeqi WP_011934404.1. NC_009481.1.
    YP_001226242.1. NC_009481.1.

    3D structure databases

    ProteinModelPortali A5GPT0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32051.SynWH7803_2519.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK24945 ; CAK24945 ; SynWH7803_2519 .
    GeneIDi 5147543.
    KEGGi syx:SynWH7803_2519.
    PATRICi 23831336. VBISynSp43824_2604.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi YAFPAIK.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH7803.

    Entry informationi

    Entry nameiASSY_SYNPW
    AccessioniPrimary (citable) accession number: A5GPT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3