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A5GNW2 (UPPP_SYNPW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:SynWH7803_2201
OrganismSynechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]
Taxonomic identifier32051 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000303038

Regions

Transmembrane50 – 7021Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane262 – 28221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A5GNW2 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 710248982BA6DE0E

FASTA28630,507
        10         20         30         40         50         60 
MESAVSEPGL LEAIWRDFVL GVVQGLTEFL PISSTAHLKI VPVLAGWGDP GVSVTAVIQL 

        70         80         90        100        110        120 
GSIVAVIAYF RADLAAVLRG ISGAVRRGQW REPEARLGIA MTIGTLPILF AGLAIKLYWP 

       130        140        150        160        170        180 
GYETSPLRSV PAIAGVSILM ALLLALAERF GPRSKQLDQV QGRDGLLVGL AQVLALIPGV 

       190        200        210        220        230        240 
SRSGSTLTAS LFDSWKRPDA ARFSFLLGIP AITIAGLVEL KDAFTEPSAG GVLPLMVGIV 

       250        260        270        280 
SAAVVSWLAI DWLLKFLQRH STWVFVIYRL LFGILLLAWW AGSGSN 

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH7803.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT971583 Genomic DNA. Translation: CAK24627.1.
RefSeqYP_001225924.1. NC_009481.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING32051.SynWH7803_2201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK24627; CAK24627; SynWH7803_2201.
GeneID5147358.
KEGGsyx:SynWH7803_2201.
PATRIC23830664. VBISynSp43824_2270.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAEYLFHER.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_SYNPW
AccessionPrimary (citable) accession number: A5GNW2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families