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A5GNW2

- UPPP_SYNPW

UniProt

A5GNW2 - UPPP_SYNPW

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:SynWH7803_2201
    OrganismiSynechococcus sp. (strain WH7803)
    Taxonomic identifieri32051 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001566: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Undecaprenyl-diphosphatasePRO_0000303038Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi32051.SynWH7803_2201.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalUniRule annotationAdd
    BLAST
    Transmembranei97 – 11721HelicalUniRule annotationAdd
    BLAST
    Transmembranei127 – 14721HelicalUniRule annotationAdd
    BLAST
    Transmembranei165 – 18521HelicalUniRule annotationAdd
    BLAST
    Transmembranei200 – 22021HelicalUniRule annotationAdd
    BLAST
    Transmembranei230 – 25021HelicalUniRule annotationAdd
    BLAST
    Transmembranei262 – 28221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiEYLFHER.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5GNW2-1 [UniParc]FASTAAdd to Basket

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    MESAVSEPGL LEAIWRDFVL GVVQGLTEFL PISSTAHLKI VPVLAGWGDP    50
    GVSVTAVIQL GSIVAVIAYF RADLAAVLRG ISGAVRRGQW REPEARLGIA 100
    MTIGTLPILF AGLAIKLYWP GYETSPLRSV PAIAGVSILM ALLLALAERF 150
    GPRSKQLDQV QGRDGLLVGL AQVLALIPGV SRSGSTLTAS LFDSWKRPDA 200
    ARFSFLLGIP AITIAGLVEL KDAFTEPSAG GVLPLMVGIV SAAVVSWLAI 250
    DWLLKFLQRH STWVFVIYRL LFGILLLAWW AGSGSN 286
    Length:286
    Mass (Da):30,507
    Last modified:June 12, 2007 - v1
    Checksum:i710248982BA6DE0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK24627.1.
    RefSeqiWP_011934089.1. NC_009481.1.
    YP_001225924.1. NC_009481.1.

    Genome annotation databases

    EnsemblBacteriaiCAK24627; CAK24627; SynWH7803_2201.
    GeneIDi5147358.
    KEGGisyx:SynWH7803_2201.
    PATRICi23830664. VBISynSp43824_2270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK24627.1 .
    RefSeqi WP_011934089.1. NC_009481.1.
    YP_001225924.1. NC_009481.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32051.SynWH7803_2201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK24627 ; CAK24627 ; SynWH7803_2201 .
    GeneIDi 5147358.
    KEGGi syx:SynWH7803_2201.
    PATRICi 23830664. VBISynSp43824_2270.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi EYLFHER.
    OrthoDBi EOG6QP13M.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH7803.

    Entry informationi

    Entry nameiUPPP_SYNPW
    AccessioniPrimary (citable) accession number: A5GNW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3