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A5GN53

- PYRF_SYNPW

UniProt

A5GN53 - PYRF_SYNPW

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, SynWH7803_1942
Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181Substrate By similarity
Binding sitei39 – 391Substrate By similarity
Active sitei68 – 681Proton donor By similarity
Binding sitei130 – 1301Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei221 – 2211Substrate; via amide nitrogen By similarity
Binding sitei222 – 2221Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:SynWH7803_1942
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000065956Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi32051.SynWH7803_1942.

Structurei

3D structure databases

ProteinModelPortaliA5GN53.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 7510Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OMAiDIPNTMR.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GN53-1 [UniParc]FASTAAdd to Basket

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MASLRSAHPA DRIIVALDGM APEQALAFAA QVEGLRWVKV GLELFVQAGP    50
EVVAQLREQG LRVFLDLKFH DIPATMAGAC RRAAALGAEL ITVHACAGSE 100
ALKAAQAAAV EGAQGAGQPA PTLLAVTVLT SWEEQRLQRE LAITQGIAER 150
VPALAQLSAT AGIGGCVCSP LEAAALRAQH PEPFALVTPG IRPKGAAVGD 200
QARVMGPAEA IAAGASQLVI GRPITKAEDP SAAFAACCGE LLG 243
Length:243
Mass (Da):24,786
Last modified:June 12, 2007 - v1
Checksum:i469E2D20D0614E00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK24368.1.
RefSeqiWP_011933838.1. NC_009481.1.
YP_001225665.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK24368; CAK24368; SynWH7803_1942.
GeneIDi5147210.
KEGGisyx:SynWH7803_1942.
PATRICi23830110. VBISynSp43824_2000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK24368.1 .
RefSeqi WP_011933838.1. NC_009481.1.
YP_001225665.1. NC_009481.1.

3D structure databases

ProteinModelPortali A5GN53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32051.SynWH7803_1942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK24368 ; CAK24368 ; SynWH7803_1942 .
GeneIDi 5147210.
KEGGi syx:SynWH7803_1942.
PATRICi 23830110. VBISynSp43824_2000.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OMAi DIPNTMR.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiPYRF_SYNPW
AccessioniPrimary (citable) accession number: A5GN53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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